Fmoc-D-His(Trt)-OH

CAS 135610-90-1C40H33N3O4Chemical Synthesis

Fmoc-D-His(Trt)-OH (CAS: 135610-90-1) is a protected D-histidine derivative used extensively in peptide synthesis. Its chemical formula is C40H33N3O4, with a molecular weight of 619.71 g/mol. The compound features the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the alpha-amino function and a trityl (Trt) group on the imidazole nitrogen of D-histidine. This combination facilitates controlled peptide chain elongation in solid-phase synthesis and solution-phase methodologies. Available from Tech Serve Solutions.

IUPAC: Fmoc-N(im)-trityl-D-histidine
Synonyms: Fmoc-D-His(Trt)-OH

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Fmoc-D-His(Trt)-OH (C40H33N3O4) — chemical structure, CAS 135610-90-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistryStandard Fmoc-D-Amino Acids

01 /Applications

Solid-Phase Peptide Synthesis (SPPS)

Fmoc-D-His(Trt)-OH is a key building block in SPPS for incorporating D-histidine residues into peptide sequences. The Fmoc group allows for orthogonal deprotection strategies, while the trityl group offers robust protection for the imidazole side chain during coupling steps.

Chemical Biology Research

This derivative enables the synthesis of complex peptides and peptidomimetics for investigating biological pathways, protein-ligand interactions, and enzyme mechanisms where modified histidine residues are crucial.

Pharmaceutical Intermediate Synthesis

Used in the development of novel therapeutic agents, Fmoc-D-His(Trt)-OH aids in the construction of peptide-based drugs or drug candidates that require specific histidine modifications for efficacy or stability.

Development of Peptide Libraries

Facilitates the creation of diverse peptide libraries for high-throughput screening in drug discovery and proteomics, allowing for the systematic exploration of structure-activity relationships.

02 /Properties

Molecular weight	619.71
Empirical formula	C40H33N3O4
Assay	97% (HPLC)
Optical activity	[α]22/D -85.0°, c = 1% in chloroform
Storage temperature	2-8°C
Melting point	141-146 °C

03 /Identifiers & registry

CAS number

135610-90-1

MDL number

MFCD00077061

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is Fmoc-D-His(Trt)-OH used for?

Fmoc-D-His(Trt)-OH is primarily used as a protected building block in peptide synthesis, particularly for incorporating D-histidine residues into peptide chains using Fmoc chemistry in solid-phase or solution-phase methods.

What are the CAS number and chemical formula for Fmoc-D-His(Trt)-OH?

The CAS number is 135610-90-1, and the chemical formula is C40H33N3O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-D-His(Trt)-OH with a purity of 97% (HPLC). This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

What are the safety and handling considerations for Fmoc-D-His(Trt)-OH?

This compound is classified under WGK Germany 3, indicating a high hazard to water. It should be handled with appropriate personal protective equipment in a well-ventilated area, avoiding release into the environment.