Fmoc-D-Gln(Trt)-OH
Fmoc-D-Gln(Trt)-OH (CAS: 200623-62-7) is a protected amino acid derivative with the molecular formula C39H34N2O5. This compound features the Fmoc protecting group on the amine and a trityl group on the glutamine side chain, facilitating its use in solid-phase peptide synthesis. It is a crucial building block for incorporating D-glutamine into peptide chains, particularly in research settings for developing novel peptides with specific biological activities or structural properties.
- IUPAC
- Fmoc-N-trityl-D-glutamine
Peptide Synthesis
Fmoc-D-Gln(Trt)-OH is extensively used in solid-phase peptide synthesis (SPPS) employing the Fmoc/tBu strategy. The trityl protecting group on the side chain offers stability during peptide elongation and is selectively removed under specific cleavage conditions.
Chemical Biology Research
This D-amino acid derivative serves as a key component in the synthesis of peptides designed for chemical biology studies. It allows for the investigation of peptide structure-activity relationships and the development of peptidomimetics.
Pharmaceutical Intermediate
Fmoc-D-Gln(Trt)-OH acts as a valuable intermediate in the synthesis of complex pharmaceutical compounds and peptide-based drugs. Its specific stereochemistry and protected functionalities are essential for building targeted therapeutic molecules.
Biochemical Tool Development
Researchers utilise Fmoc-D-Gln(Trt)-OH to construct peptides with modified properties, such as enhanced stability or altered receptor binding, for use as tools in biochemical assays and drug discovery platforms.
| Molecular weight | 610.70 |
|---|---|
| Empirical formula | C39H34N2O5 |
| Assay | 97% |
| Optical activity | [α]22/D +13.4°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Melting point | 232-237 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Gln(Trt)-OH used for?
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Fmoc-D-Gln(Trt)-OH is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS), particularly for incorporating D-glutamine residues into peptide chains for research in chemical biology, pharmaceutical development, and biochemical tool creation.
What is the CAS number and formula for Fmoc-D-Gln(Trt)-OH?
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The CAS number for Fmoc-D-Gln(Trt)-OH is 200623-62-7, and its empirical formula (Hill notation) is C39H34N2O5.
What grade and purity does Tech Serve Solutions supply for Fmoc-D-Gln(Trt)-OH?
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Tech Serve Solutions supplies Fmoc-D-Gln(Trt)-OH with a minimum assay of 97%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should Fmoc-D-Gln(Trt)-OH be stored and handled?
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Fmoc-D-Gln(Trt)-OH should be stored refrigerated at 2-8°C. While specific hazard data is not detailed, standard laboratory practices for handling fine chemicals should be followed, including avoiding dust formation and ensuring adequate ventilation.
How is Fmoc-D-Gln(Trt)-OH shipped and exported?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. Fmoc-D-Gln(Trt)-OH is carefully packed to maintain its integrity during transit and exported according to international shipping regulations for chemical products.
How can I request a sample or quote for Fmoc-D-Gln(Trt)-OH?
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To request a sample or a quotation for Fmoc-D-Gln(Trt)-OH, please contact the Tech Serve Solutions sales team through our website or by phone, providing the product name and CAS number (200623-62-7).
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