Fmoc-D-Glu(OtBu)-OH
Fmoc-D-Glu(OtBu)-OH (CAS: 104091-08-9), a protected D-glutamic acid derivative with the molecular formula C24H27NO6, is a vital building block in peptide synthesis. Its tert-butyl ester and Fmoc protecting groups allow for selective deprotection and coupling. This compound is essential for introducing D-glutamic acid residues into peptides, contributing to the study of peptide structure-activity relationships and the development of novel peptidomimetics and pharmaceuticals.
- IUPAC
- Fmoc-D-glutamic acid 5-tert-butyl ester
- Synonyms
- Fmoc-D-glutamic acid 5-tert-butyl ester
Peptide Synthesis
Serves as a crucial protected amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling the incorporation of D-glutamic acid into peptide chains. The Fmoc and tert-butyl protecting groups facilitate controlled sequential coupling.
Chemical Biology Research
Used in the construction of peptides and peptidomimetics for investigating biological processes, protein interactions, and enzyme mechanisms. Its inclusion can modulate peptide conformation and receptor binding.
Medicinal Chemistry
A valuable intermediate in the synthesis of novel therapeutic agents and drug candidates, particularly those incorporating non-natural amino acids to enhance stability or activity.
Organic Synthesis
Employed as a chiral building block in complex organic synthesis, leveraging its defined stereochemistry and functional groups for the creation of intricate molecular architectures.
| Molecular weight | 425.47 |
|---|---|
| Empirical formula | C24H27NO6 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]/D +4.5±1, c = 1 in acetic acid: water (4:1) |
| Storage temperature | 2-8°C |
| Melting point | 83-89 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Glu(OtBu)-OH used for?
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Fmoc-D-Glu(OtBu)-OH is primarily used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis, as well as in chemical biology and medicinal chemistry research for constructing peptides and peptidomimetics.
What are the CAS number and formula for Fmoc-D-Glu(OtBu)-OH?
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The CAS number for Fmoc-D-Glu(OtBu)-OH is 104091-08-9, and its molecular formula is C24H27NO6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-D-Glu(OtBu)-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations for Fmoc-D-Glu(OtBu)-OH?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. The compound is classified with WGK Germany 3, indicating a hazard to water. Store at 2-8°C.
How is Fmoc-D-Glu(OtBu)-OH shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. We handle all aspects of packaging, shipping, and export documentation to ensure safe and compliant delivery worldwide.
How can I request a sample or quote for Fmoc-D-Glu(OtBu)-OH?
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To request a sample or quote, please contact our sales team through the provided channels on our website, specifying the product name (Fmoc-D-Glu(OtBu)-OH) and CAS number (104091-08-9).
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