3,4-Dihydro-2H-pyran
3,4-Dihydro-2H-pyran (CAS: 110-87-2), also known by its molecular formula C5H8O and a molecular weight of 84.12 g/mol, is a cyclic ether. This colourless liquid is widely recognised as an effective OH-protecting reagent in organic synthesis. It is a valuable intermediate for chemical modifications, particularly in the preparation of pharmaceuticals and complex organic molecules, offering a reliable method for temporary hydroxyl group protection.
- Synonyms
- 3,4-Dihydro-2H-pyranDihydropyran2,3-Dihydropyran
Hydroxyl Group Protection
3,4-Dihydro-2H-pyran serves as a primary reagent for the protection of hydroxyl (-OH) groups in organic synthesis. Its reaction with alcohols under acidic conditions forms tetrahydropyranyl (THP) ethers, which are stable to a wide range of reaction conditions but can be readily cleaved when needed.
Intermediate in Organic Synthesis
Beyond its role as a protecting group, this compound is a versatile building block. It can participate in various addition reactions and is used in the synthesis of more complex organic structures, contributing to the development of novel compounds in research and industrial settings.
Reagent in Pharmaceutical Chemistry
In the pharmaceutical industry, precise control over functional groups is critical. 3,4-Dihydro-2H-pyran is employed to selectively protect hydroxyl functionalities during multi-step syntheses of active pharmaceutical ingredients (APIs), ensuring reaction pathways proceed as intended.
| Molecular weight | 84.12 |
|---|---|
| Empirical formula | C5H8O |
| Assay | 97% |
| Boiling point | 86 °C(lit.) |
| Density | 0.922 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.440(lit.) |
| Vapour density | 2.9 (vs air) |
| Melting point | −70 °C(lit.) |
| Application | Widely used OH-protecting reagent.1 |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -16 °C / 3.2 °F |
| Transport (UN / ADR) | UN 2376 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-Dihydro-2H-pyran used for?
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3,4-Dihydro-2H-pyran (CAS: 110-87-2) is primarily used as a hydroxyl (-OH) protecting reagent in organic synthesis. It is also a versatile intermediate for constructing more complex organic molecules, including in the pharmaceutical sector.
What is the CAS number and formula for 3,4-Dihydro-2H-pyran?
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The CAS number for 3,4-Dihydro-2H-pyran is 110-87-2. Its empirical formula is C5H8O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies 3,4-Dihydro-2H-pyran with an assay of 97%. This is a technical or research grade chemical. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial standard unless explicitly stated otherwise in the product documentation.
How should 3,4-Dihydro-2H-pyran be handled safely?
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3,4-Dihydro-2H-pyran is a highly flammable liquid and vapour (H225) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle in a well-ventilated area, away from ignition sources. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, is essential. Always consult the Safety Data Sheet (SDS) before use.
How is 3,4-Dihydro-2H-pyran shipped or exported?
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3,4-Dihydro-2H-pyran is shipped and exported in compliance with transportation regulations for hazardous materials. It is classified under UN 2376, Hazard Class 3, Packing Group II, indicating it is a flammable liquid.
How can I request a quote or sample?
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To request a quote or a sample of 3,4-Dihydro-2H-pyran, please contact the Tech Serve Solutions sales team through our website or by phone. Provide your specific requirements and shipping details.
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