Fmoc-D-Cha-OH
Fmoc-D-Cha-OH (CAS: 144701-25-7, C24H27NO4) is a protected D-amino acid derivative. It features the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the amine nitrogen and a cyclohexyl side chain attached to the alpha-carbon of D-alanine. With a molecular weight of 393.48 g/mol, this compound is primarily utilised in solid-phase peptide synthesis (SPPS) and in the construction of peptides containing unnatural amino acids for research purposes.
- IUPAC
- Fmoc-3-cyclohexyl-D-alanine
- Synonyms
- Fmoc-3-cyclohexyl-D-alanine
Peptide Synthesis
Fmoc-D-Cha-OH serves as a crucial building block in solid-phase peptide synthesis (SPPS) for incorporating the D-cyclohexylalanine residue into peptide chains. This enables the creation of peptides with modified structures and properties.
Chemical Biology Research
The compound is employed in chemical biology to synthesise peptides with unnatural amino acids. These modified peptides can be used to probe biological systems, develop enzyme inhibitors, or create novel therapeutic agents.
Drug Discovery and Development
Incorporating D-cyclohexylalanine can influence a peptide's pharmacokinetic and pharmacodynamic profile, making Fmoc-D-Cha-OH valuable in the design and synthesis of new drug candidates.
Organic Synthesis
As a protected amino acid derivative, it is a useful reagent in complex organic synthesis pathways where precise control over amino acid incorporation is required.
| Molecular weight | 393.48 |
|---|---|
| Empirical formula | C24H27NO4 |
| Assay | ≥98.0% (TLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-D-Cha-OH primarily used for?
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Fmoc-D-Cha-OH is primarily used as a protected building block in solid-phase peptide synthesis (SPPS) for the incorporation of D-cyclohexylalanine into peptide sequences, particularly in research settings for chemical biology and drug discovery.
What are the CAS number and molecular formula of Fmoc-D-Cha-OH?
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The CAS number for Fmoc-D-Cha-OH is 144701-25-7, and its molecular formula is C24H27NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-D-Cha-OH?
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Tech Serve Solutions supplies Fmoc-D-Cha-OH with a purity of ≥98.0% (determined by TLC). This product is typically intended for research and laboratory use and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for Fmoc-D-Cha-OH?
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When handling Fmoc-D-Cha-OH, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A respirator filter such as type N95 (US) or P1 (EN143) is recommended for respiratory protection. The compound is classified under WGK Germany 3, indicating a high hazard to water.
How is Fmoc-D-Cha-OH typically shipped and exported?
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As a specialist supplier, Tech Serve Solutions exports fine chemicals globally. Fmoc-D-Cha-OH, requiring specific storage conditions (2-8°C), is packaged and shipped according to international regulations for chemical transport to maintain its integrity and comply with all relevant import/export laws.
How can I request a quote or sample for Fmoc-D-Cha-OH?
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To request a quote or obtain a sample of Fmoc-D-Cha-OH, please contact our sales department through the website or by phone. Our team will assist you with your inquiry and provide the necessary information.
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