Fmoc-Arg(Mtr)-OH
Fmoc-Arg(Mtr)-OH (CAS: 98930-01-9), a derivative of L-arginine with the molecular formula C31H36N4O7S and a molecular weight of 608.71 g/mol, is a crucial building block in peptide synthesis. It is primarily employed in solid-phase peptide synthesis (SPPS) and solution-phase synthesis. This compound features the Fmoc protecting group on the alpha-amino group and the Mtr protecting group on the guanidino moiety of arginine, facilitating controlled peptide chain elongation.
- IUPAC
- Nα-Fmoc-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine,Nα-Fmoc-Nω-MTR-L-arginine
- Synonyms
- Nα-Fmoc-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginineNα-Fmoc-Nω-MTR-L-arginine
Solid-Phase Peptide Synthesis (SPPS)
Fmoc-Arg(Mtr)-OH is widely utilized in SPPS for the construction of complex peptides. The Nα-Fmoc group is readily cleaved under mild basic conditions, allowing for sequential addition of amino acids, while the Mtr protecting group offers stability during peptide assembly and is removed in the final deprotection step.
Solution-Phase Peptide Synthesis
In addition to SPPS, this derivative is also employed in solution-phase peptide synthesis. Its protected nature allows for controlled coupling reactions, making it valuable for synthesizing shorter peptide fragments or modified peptides in solution.
Chemical Biology Research
Researchers in chemical biology use Fmoc-Arg(Mtr)-OH for synthesizing peptides with specific biological functions or for developing peptide-based therapeutics. Its structure enables the incorporation of arginine into peptides where its positive charge and side chain are critical for molecular interactions.
Analytical Standards
As indicated by its inclusion in analytical standard indexes, Fmoc-Arg(Mtr)-OH can serve as a reference standard in chromatographic and analytical methods for the identification and quantification of peptides and related compounds.
| Molecular weight | 608.71 |
|---|---|
| Empirical formula | C31H36N4O7S |
| Assay | ≥98.0% (TLC) |
| Storage temperature | −20°C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Arg(Mtr)-OH used for?
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Fmoc-Arg(Mtr)-OH is primarily used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis. The Fmoc group protects the alpha-amino function, and the Mtr group protects the guanidino function of arginine, enabling controlled peptide chain elongation.
What is the CAS number and molecular formula for Fmoc-Arg(Mtr)-OH?
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The CAS number for Fmoc-Arg(Mtr)-OH is 98930-01-9, and its molecular formula is C31H36N4O7S.
What grade and purity does Tech Serve Solutions supply for Fmoc-Arg(Mtr)-OH?
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Tech Serve Solutions supplies Fmoc-Arg(Mtr)-OH with an assay of ≥98.0% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling Fmoc-Arg(Mtr)-OH?
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Fmoc-Arg(Mtr)-OH is classified with a Warning signal word. It carries hazard statements H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H332 (Harmful if inhaled), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is Fmoc-Arg(Mtr)-OH stored and shipped?
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Fmoc-Arg(Mtr)-OH should be stored at -20°C. As a global supplier and exporter, Tech Serve Solutions ensures proper packaging and shipping protocols are followed for all chemical products.
How can I request a sample or a quote for Fmoc-Arg(Mtr)-OH?
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To request a sample or obtain a quote for Fmoc-Arg(Mtr)-OH, please contact our sales department through the website or via direct inquiry, providing your specific requirements and contact information.
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