Fmoc-Abu-OH
Fmoc-Abu-OH (CAS 135112-27-5), also known as L-2-(Fmoc-amino)butyric acid, is a protected amino acid with the molecular formula C19H19NO4 and a molecular weight of 325.36 g/mol. This compound is a valuable building block in peptide synthesis and chemical biology research. It is widely used for the introduction of unnatural amino acid residues into peptide chains, contributing to the development of novel therapeutics and research tools.
- IUPAC
- L-2-(Fmoc-amino)butyric acid
- Synonyms
- L-2-(Fmoc-amino)butyric acid
Peptide Synthesis
Fmoc-Abu-OH is utilised as a key reagent in solid-phase peptide synthesis (SPPS) and solution-phase methods. Its Fmoc protecting group allows for controlled deprotection and coupling, enabling the efficient construction of complex peptide sequences incorporating unnatural amino acid functionalities.
Chemical Biology
In chemical biology, this unnatural amino acid derivative serves as a versatile tool for probing biological systems. It can be incorporated into peptides to study protein-protein interactions, enzyme mechanisms, or to develop peptide-based probes and diagnostics.
Drug Discovery and Development
The unique properties imparted by the Abu residue can enhance the pharmacokinetic or pharmacodynamic profiles of peptide-based drug candidates. Fmoc-Abu-OH facilitates the synthesis of modified peptides for therapeutic applications and lead optimisation.
Analytical Standards
As an analytical standard, Fmoc-Abu-OH is employed in chromatography and other analytical techniques for identification and quantification purposes, ensuring the quality and integrity of related chemical processes and products.
| Molecular weight | 325.36 |
|---|---|
| Empirical formula | C19H19NO4 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −22.0±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Abu-OH primarily used for?
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Fmoc-Abu-OH is primarily used in peptide synthesis and chemical biology for the incorporation of unnatural amino acid residues into peptide chains. It serves as a valuable building block for research and drug discovery.
What is the CAS number and molecular formula for Fmoc-Abu-OH?
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The CAS number for Fmoc-Abu-OH is 135112-27-5, and its molecular formula is C19H19NO4.
What grade and purity does Tech Serve Solutions supply for Fmoc-Abu-OH?
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Tech Serve Solutions supplies Fmoc-Abu-OH with an assay of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product documentation.
How should Fmoc-Abu-OH be handled and stored?
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Fmoc-Abu-OH requires handling with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 or P1 respirator filter. It should be stored at refrigeration temperatures between 2-8°C to maintain its stability.
Is Fmoc-Abu-OH a controlled substance?
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The provided data does not indicate that Fmoc-Abu-OH is a controlled substance.
How are Tech Serve Solutions' chemicals packed, shipped, and exported?
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Tech Serve Solutions offers expert packing, secure shipping, and global export services for all its chemical products, adhering to international regulations and best practices.
How can I request a sample or a quote for Fmoc-Abu-OH?
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To request a sample or a quote for Fmoc-Abu-OH, please contact our sales team through the website or by telephone. We are happy to assist with your specific requirements.
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