Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate
Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate (CAS: 84028-89-7; C6H9F3O5S; MW: 250.19) is a chiral triflate ester utilized in asymmetric synthesis and organic building blocks. It serves as a valuable intermediate in chemical synthesis, particularly for creating complex chiral molecules. Its triflate group makes it an excellent leaving group, facilitating various transformations. Available from Tech Serve Solutions with high purity.
- IUPAC
- Ethyl O-trifluoromethanesulfonyl-D-lactate,Ethyl D-lactate 2-O-triflate
- Synonyms
- Ethyl O-trifluoromethanesulfonyl-D-lactateEthyl D-lactate 2-O-triflate

Chiral Building Block
This compound is a key chiral building block for the synthesis of enantiomerically pure molecules. Its defined stereochemistry is crucial for constructing stereospecific targets in pharmaceuticals and fine chemicals.
Asymmetric Synthesis Intermediate
As an intermediate in asymmetric synthesis, it allows for the introduction of specific stereocenters. The triflate moiety is highly reactive, enabling a range of coupling and substitution reactions under controlled conditions.
Organic Synthesis Reagent
It functions as a versatile reagent in organic synthesis, enabling the formation of new carbon-carbon and carbon-heteroatom bonds. Its utility spans various research and development applications in chemistry.
| Molecular weight | 250.19 |
|---|---|
| Empirical formula | C6H9F3O5S |
| Assay | ≥97.0% |
| Density | 1.342 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.375 |
| Optical activity | [α]20/D +42±2°, neat |
| Storage temperature | −20°C |
| Contains / stabiliser | ~1% magnesium oxide as stabilizer (white solid) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate used for?
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Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate is primarily used as a chiral building block and intermediate in asymmetric synthesis and broader organic chemical synthesis.
What is the CAS number and formula?
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The CAS number is 84028-89-7, and the empirical formula is C6H9F3O5S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥97.0%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate be handled?
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This compound is classified as Danger, with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including full-face respirators, gloves, and goggles, is essential. Handle with extreme care in a well-ventilated area.
Is this chemical shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate, and can facilitate international shipments.
How can I request a sample or quote?
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Please contact our sales department through the website or by phone to request a sample or a formal quotation for Ethyl (R)-2-(trifluoromethylsulfonyloxy)propionate.
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