Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate
Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate (CAS: 7149-65-7; C7H11NO3; MW: 157.17) is a chiral building block derived from L-glutamic acid. This enantiomerically pure compound is valuable in chemical synthesis and peptide chemistry. It serves as a key intermediate for the preparation of various biologically active molecules and unnatural amino acid derivatives. Its defined stereochemistry makes it an important reagent in stereoselective synthesis and chemical biology research.
- IUPAC
- (S)-5-Oxoproline ethyl ester,L-Pyroglutamic acid ethyl ester
- Synonyms
- (S)-5-Oxoproline ethyl esterL-Pyroglutamic acid ethyl ester
Chiral Building Block in Synthesis
Utilised as a chiral synthon for constructing complex organic molecules. Its pyrrolidone ring and ester functionality allow for diverse chemical transformations, enabling the synthesis of enantiomerically enriched products.
Peptide Chemistry Reagent
Serves as a component in peptide synthesis, particularly for incorporating unnatural amino acid analogues. It is crucial for the development of modified peptides with enhanced stability or novel biological activities.
Chemical Biology Research
Employed in chemical biology to study protein structure-function relationships or to develop molecular probes. Its unique stereochemistry is essential for specific interactions in biological systems.
Synthesis of Pyroglutamine Derivatives
Acts as a precursor for various pyroglutamine derivatives, which are found in numerous natural products and pharmaceuticals. This facilitates the exploration of novel therapeutic agents.
| Molecular weight | 157.17 |
|---|---|
| Empirical formula | C7H11NO3 |
| Assay | 98% |
| Boiling point | 176 °C/12 mmHg(lit.) |
| Optical activity | [α]19/D +3.3°, c = 10 in ethanol |
| Optical purity | enantiomeric ratio: ≥99:1 (GC) |
| Melting point | 47-51 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate used for?
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Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate is primarily used as a chiral building block in chemical synthesis, a reagent in peptide chemistry, and in chemical biology research for the preparation of unnatural amino acid derivatives and other complex molecules.
What are the CAS number and formula for this compound?
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The CAS number is 7149-65-7 and the empirical formula is C7H11NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations?
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This compound is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Use a dust mask type N95 (US), wear eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
Is this chemical shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate.
How can I request a sample or quote?
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Please use the 'Request a Quote' or 'Request a Sample' button on our product page, or contact our sales team directly.
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