Boc-His(Tos)-OH
Boc-His(Tos)-OH (CAS: 35899-43-5) is a protected derivative of L-histidine with the chemical formula C18H23N3O6S and a molecular weight of 409.46 g/mol. This compound is vital in peptide synthesis, serving as a building block for creating complex peptide chains where the imidazole nitrogen of histidine requires protection. Its defined structure and purity make it suitable for advanced chemical research and development.
- IUPAC
- Nα-Boc-N(im)-tosyl-L-histidine
- Synonyms
- Nα-Boc-N(im)-tosyl-L-histidine
Peptide Synthesis
Boc-His(Tos)-OH is a key reagent in solid-phase and solution-phase peptide synthesis. The Boc (tert-butyloxycarbonyl) group protects the alpha-amino function, while the Tosyl (p-toluenesulfonyl) group protects the imidazole nitrogen of histidine, enabling controlled coupling reactions in the construction of specific peptide sequences.
Chemical Biology Research
As a modified amino acid derivative, it is employed in research settings to investigate protein structure-function relationships and to develop novel biologically active peptides. Its use allows for the precise incorporation of histidine residues into peptides for studying enzyme mechanisms or receptor interactions.
Organic Synthesis
Beyond peptide chemistry, Boc-His(Tos)-OH can be utilized in complex organic synthesis strategies where a protected histidine moiety is required. Its functional groups allow for diverse chemical transformations in the creation of intricate molecular architectures.
| Molecular weight | 409.46 |
|---|---|
| Empirical formula | C18H23N3O6S |
| Assay | ≥98.0% (TLC) |
| Optical activity | [α]20/D +16±1°, c = 1% in methanol |
| Storage temperature | −20°C |
| Melting point | ~125 °C (dec.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-His(Tos)-OH used for?
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Boc-His(Tos)-OH is primarily used as a protected amino acid derivative in peptide synthesis and chemical biology research, allowing for controlled incorporation of histidine residues into peptide chains.
What is the CAS number and chemical formula for Boc-His(Tos)-OH?
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The CAS number for Boc-His(Tos)-OH is 35899-43-5, and its chemical formula is C18H23N3O6S.
What grade and purity does Tech Serve Solutions supply for Boc-His(Tos)-OH?
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Tech Serve Solutions supplies Boc-His(Tos)-OH with an assay of ≥98.0% (TLC). This product is supplied for research and laboratory use; TSS does not represent it as USP, BP, EP, or any other pharmacopoeial grade.
How should Boc-His(Tos)-OH be handled and stored?
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Handle Boc-His(Tos)-OH with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter. Store at -20°C.
Is Boc-His(Tos)-OH a controlled substance?
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The provided data does not indicate that Boc-His(Tos)-OH is a controlled substance.
How is Boc-His(Tos)-OH packed, shipped, and exported?
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Boc-His(Tos)-OH is carefully packed according to industry standards for stability and safety during transport. Tech Serve Solutions is experienced in global exporting of fine chemicals.
How can I request a quote or sample for Boc-His(Tos)-OH?
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Please contact our sales team through the website or by phone to request a quotation or a sample of Boc-His(Tos)-OH. Our team will be pleased to assist you.
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