Boc-His(Dnp)-OH

CAS 25024-53-7C17H19N5O8Chemical Synthesis

Boc-His(Dnp)-OH, CAS 25024-53-7, is a key derivative of L-histidine with the empirical formula C17H19N5O8 and a molecular weight of 421.36 g/mol. This compound features both an Nα-Boc protecting group and an N(im)-2,4-dinitrophenyl protecting group on the imidazole ring. It serves as a valuable building block in peptide synthesis, particularly for introducing modified histidine residues into peptide chains and for applications in chemical biology.

IUPAC: Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine
Synonyms: Nα-Boc-N(im)-2,4-dinitrophenyl-L-histidine

Email us

Boc-His(Dnp)-OH (C17H19N5O8) — chemical structure, CAS 25024-53-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisHistidinePeptide Chemistry

01 /Applications

Peptide Synthesis

Utilised as a protected amino acid in solid-phase or solution-phase peptide synthesis. The orthogonal protecting groups allow for selective deprotection and elongation of peptide chains, facilitating the construction of complex peptide sequences containing histidine.

Chemical Biology

Employed in studies investigating the role of histidine in biological systems. The dinitrophenyl group can serve as a chromophore for spectroscopic studies or as a photo-labelling agent.

Medicinal Chemistry

Serves as an intermediate in the synthesis of potential pharmaceutical agents. Its structure allows for further modification to explore structure-activity relationships in drug discovery programmes.

02 /Properties

Molecular weight	421.36
Empirical formula	C17H19N5O8
Assay	≥98.0% (TLC)
Optical activity	[α]20/D +61±3°, c = 1% in ethyl acetate

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

25024-53-7

MDL number

MFCD00065966

Beilstein registry

771922

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-His(Dnp)-OH used for?

Boc-His(Dnp)-OH is primarily used as a protected amino acid building block in peptide synthesis and in chemical biology research, particularly for introducing modified histidine residues into peptides.

What is the CAS number and formula for Boc-His(Dnp)-OH?

The CAS number is 25024-53-7, and the empirical formula is C17H19N5O8.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-His(Dnp)-OH with a purity of ≥98.0% (TLC). This product is not represented as USP, BP, EP, or any other pharmacopoeia grade; it is supplied for research and laboratory use.

What safety precautions should be taken when handling Boc-His(Dnp)-OH?

Handle Boc-His(Dnp)-OH with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK rating of 3 in Germany, indicating it is hazardous to water.

How is Boc-His(Dnp)-OH packed and shipped?

Boc-His(Dnp)-OH is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical compounds.

How can I request a sample or quote for Boc-His(Dnp)-OH?

To request a sample or a quotation for Boc-His(Dnp)-OH, please contact the Tech Serve Solutions sales team through our website or by phone, referencing the product name and CAS number.