1-Chloro-2-fluorobenzene
1-Chloro-2-fluorobenzene (CAS: 348-51-6), with the chemical formula ClC6H4F, is a halogenated aromatic compound. This versatile building block possesses a molecular weight of 130.55 g/mol. It is primarily utilised in chemical synthesis, particularly as a key intermediate in the development of novel organic compounds and pharmaceuticals. Its unique structure, featuring both chlorine and fluorine substituents on a benzene ring, makes it valuable for introducing specific functionalities in complex molecular designs.
Organic Synthesis Intermediate
1-Chloro-2-fluorobenzene serves as a crucial building block in organic synthesis. It is employed in reactions for creating more complex halogenated aromatic compounds and heterocyclic structures.
Research and Development
This compound is utilised in research laboratories for the development of new chemical entities. Its specific reactivity profile makes it suitable for various synthetic pathways in drug discovery and materials science.
NMR Spectroscopy Studies
1-Chloro-2-fluorobenzene has been used in specific analytical applications, such as in 9F NMR analysis, to study biochemical conversion processes involving related anilines.
Traceless Synthesis
It has been applied in microwave-assisted synthesis techniques, specifically in the traceless rapid synthesis of benzimidazolones using Ameba resin.
| Molecular weight | 130.55 |
|---|---|
| Linear formula | ClC6H4F |
| Assay | 99% |
| Boiling point | 137-138 °C(lit.) |
| Density | 1.244 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.501(lit.) |
| Application | 1-Chloro-2-fluorobenzene was used in the 9F NMR analysis of conversion of 3,4-fluoro- and 3-chloro-4-fluoroaniline by Rhodococcus sp. strain1. It was used in microwave-assisted traceless rapid synthesis of benzimidazolones on Ameba resin2. |
| Melting point | −43-−42 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 31 °C / 87.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/38 |
| Safety statements (S) | 16-26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Chloro-2-fluorobenzene used for?
+
1-Chloro-2-fluorobenzene is used as an intermediate in organic synthesis, in research and development for new chemical entities, in NMR spectroscopy studies, and in traceless synthesis methods.
What is the CAS number and chemical formula for 1-Chloro-2-fluorobenzene?
+
The CAS number is 348-51-6 and the chemical formula is ClC6H4F.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-Chloro-2-fluorobenzene with a purity of 99% assay. We do not represent this product as USP, BP, or EP grade.
How is 1-Chloro-2-fluorobenzene handled and stored?
+
1-Chloro-2-fluorobenzene is a flammable liquid and vapour (H226), causes skin irritation (H315) and serious eye irritation (H319). It should be handled with appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Store in a well-ventilated place, away from heat and open flames.
Does Tech Serve Solutions export 1-Chloro-2-fluorobenzene?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1-Chloro-2-fluorobenzene.
How can I request a quote or sample for 1-Chloro-2-fluorobenzene?
+
Please contact our sales team via the website or phone to request a quote or sample for 1-Chloro-2-fluorobenzene.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis