1-Chloro-2,4-difluorobenzene

CAS 1435-44-5ClC6H3F2Chemical Synthesis

1-Chloro-2,4-difluorobenzene (CAS: 1435-44-5; Formula: ClC₆H₃F₂; MW: 148.54) is a halogenated aromatic compound. It serves as a valuable building block in organic synthesis, particularly for introducing the 2,4-difluorophenyl moiety into target molecules. Its reactivity makes it a key intermediate in the development of pharmaceuticals and agrochemicals.

Synonyms: ClC6H3F2

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1-Chloro-2,4-difluorobenzene (ClC6H3F2) — chemical structure, CAS 1435-44-5; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Pharmaceutical Intermediate

1-Chloro-2,4-difluorobenzene is utilised in the synthesis of active pharmaceutical ingredients (APIs). It is a crucial precursor for developing new therapeutic agents due to the common presence of the difluorophenyl group in many drug candidates.

Agrochemical Synthesis

This compound finds application in the creation of novel pesticides, herbicides, and fungicides. The incorporation of fluorine atoms can enhance the biological activity and metabolic stability of agrochemical products.

Organic Building Block

As a versatile building block, 1-Chloro-2,4-difluorobenzene enables the construction of complex organic molecules. Its structure allows for various synthetic transformations, supporting research and development in diverse chemical fields.

02 /Properties

Molecular weight	148.54
Linear formula	ClC6H3F2
Assay	98%
Boiling point	127 °C(lit.)
Density	1.353 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.475(lit.)

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	33 °C / 91.4 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	2
Hazard codes (EU)	Xi
Risk statements (R)	10-36/37/38
Safety statements (S)	16-26-36/37/39

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1435-44-5

MDL number

MFCD00042569

PubChem substance

24860345

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1-Chloro-2,4-difluorobenzene used for?

1-Chloro-2,4-difluorobenzene is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and as a general building block in organic chemistry.

What is the CAS number and formula for 1-Chloro-2,4-difluorobenzene?

The CAS number is 1435-44-5 and the linear formula is ClC₆H₃F₂.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1-Chloro-2,4-difluorobenzene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

How is 1-Chloro-2,4-difluorobenzene handled and what are its hazards?

1-Chloro-2,4-difluorobenzene is a flammable liquid and vapour (H226), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It requires careful handling with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area. Refer to the safety data sheet for full details.

How is 1-Chloro-2,4-difluorobenzene packed, shipped, and exported?

1-Chloro-2,4-difluorobenzene is shipped according to international regulations for hazardous materials. TSS is a specialist global supplier and exporter, experienced in handling and dispatching chemicals worldwide.

How can I request a sample or quote for 1-Chloro-2,4-difluorobenzene?

To request a sample or a quotation, please contact our sales team through the website or by direct inquiry. Please specify the required quantity and your shipping destination.