Boc-Hyp(Bzl)-OH
N-Boc-O-benzyl-L-hydroxyproline (CAS: 54631-81-1, C17H23NO5) is a protected amino acid derivative. This compound serves as a valuable building block in peptide synthesis, particularly for incorporating modified proline residues into peptide chains. Its structure features a Boc protecting group on the amine and a benzyl protecting group on the hydroxyl function, facilitating controlled coupling reactions in organic synthesis and chemical biology research.
- IUPAC
- Boc-O-benzyl-L-hydroxyproline

Peptide Synthesis
Serves as a key intermediate for solid-phase and solution-phase peptide synthesis, enabling the controlled incorporation of protected hydroxyproline residues into peptide sequences. Its protected hydroxyl group allows for selective deprotection and further modification.
Organic Synthesis
Utilised as a chiral building block in complex organic synthesis, contributing to the construction of molecules with defined stereochemistry. It is valuable in the development of novel compounds and the study of chemical reactions.
Chemical Biology Research
Employed in the design and synthesis of peptides with altered biological properties, such as enhanced stability or specific receptor binding. Facilitates the study of peptide-protein interactions and the development of peptidomimetics.
Proline Derivative Chemistry
Acts as a versatile starting material for the synthesis of various proline analogues and unnatural amino acid derivatives. These modified amino acids can be used to explore structure-activity relationships in biologically active molecules.
| Molecular weight | 321.37 |
|---|---|
| Empirical formula | C17H23NO5 |
| Assay | ≥98.0% (HPLC) |
| Optical activity | [α]20/D −40±2°, c = 2% in ethanol |
| Melting point | ~70 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-O-benzyl-L-hydroxyproline used for?
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Boc-O-benzyl-L-hydroxyproline is primarily used as a protected amino acid derivative in peptide synthesis and as a chiral building block in organic synthesis and chemical biology research.
What are the CAS number and formula for Boc-O-benzyl-L-hydroxyproline?
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The CAS number is 54631-81-1 and the empirical formula is C17H23NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-O-benzyl-L-hydroxyproline with a purity of ≥98.0% (HPLC). This is a research-grade chemical and not represented as USP, BP, or EP.
How should Boc-O-benzyl-L-hydroxyproline be handled?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter if necessary. Refer to the Safety Data Sheet for detailed handling instructions.
Is Boc-O-benzyl-L-hydroxyproline a controlled substance?
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The provided data does not indicate that Boc-O-benzyl-L-hydroxyproline is a controlled substance.
How is this chemical packed, shipped, or exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and documentation for safe and compliant shipment of chemicals worldwide.
How can I request a sample or quote for Boc-O-benzyl-L-hydroxyproline?
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Please contact our customer service team via the website or phone to request a sample or a formal quotation for Boc-O-benzyl-L-hydroxyproline.
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