Bis(diisopropylamino)chlorophosphine
Bis(diisopropylamino)chlorophosphine (CAS 56183-63-2; formula [[(CH3)2CH]2N]2PCl; molar mass 266.79 g/mol) is a moisture-sensitive trivalent phosphorus(III) reagent bearing two diisopropylamino groups and a reactive P-Cl bond. Also known as chlorobis(N,N-diisopropylamino)phosphine, it is a versatile building block for preparing phosphoramidites and other organophosphorus intermediates. Tech Serve Solutions supplies it at an assay of not less than 95.0% to research and synthesis laboratories worldwide.
- IUPAC
- Chlorobis(N,N-diisopropyl)phosphoramidite,Chlorobis(N,N-diisopropylamino)phosphine,Tetraisopropylphosphorodiamidous chloride
- Synonyms
- Bis(diisopropylamino)chlorophosphineChlorobis(N,N-diisopropylamino)phosphineChlorobis(N,N-diisopropyl)phosphoramiditeTetraisopropylphosphorodiamidous chlorideBis(diisopropylamino)phosphorochloriditeN,N,N',N'-Tetraisopropylphosphorodiamidic chlorideCAS 56183-63-2
![Bis(diisopropylamino)chlorophosphine ([[(CH3)2CH]2N]2PCl) — chemical structure, CAS 56183-63-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F56183-63-2.png&w=3840&q=75)
Phosphoramidite and phosphitylating reagent synthesis
The reactive P-Cl bond reacts readily with alcohols and amines, making this chlorophosphine a key precursor for preparing diisopropylamino phosphoramidite reagents and related phosphitylating agents used in organophosphorus chemistry.
Oligonucleotide and nucleotide chemistry
Diisopropylamino chlorophosphines are widely documented intermediates en route to nucleoside phosphoramidites, which underpin solid-phase oligonucleotide synthesis. It serves as a controlled source of the bis(diisopropylamino)phosphino moiety.
Ligand and phosphorus precursor preparation
As a phosphorus(III) precursor, it is used to install phosphorus-containing functional groups and to build phosphoramidite and aminophosphine ligands for coordination and catalysis research.
General organophosphorus research synthesis
The reagent is employed in laboratory-scale synthesis where a selective, electrophilic P(III) centre is required. Reactions are typically conducted under inert, anhydrous conditions with a suitable base.
| Molecular weight | 266.79 |
|---|---|
| Linear formula | [[(CH3)2CH]2N]2PCl |
| Assay | ≥95.0% |
| Melting point | 100-104 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(diisopropylamino)chlorophosphine used for?
+
It is used mainly as a reactive phosphorus(III) building block for synthesising phosphoramidite reagents and other organophosphorus intermediates. The electrophilic P-Cl bond reacts with alcohols and amines, and the compound is a documented precursor in nucleoside phosphoramidite and oligonucleotide chemistry, as well as in the preparation of phosphorus-containing ligands.
What is the CAS number and molecular formula of Bis(diisopropylamino)chlorophosphine?
+
The CAS number is 56183-63-2 and the molecular formula is [[(CH3)2CH]2N]2PCl, with a molecular weight of 266.79 g/mol. Its MDL number is MFCD00061482 and the PubChem substance ID is 24860930. It is also known as chlorobis(N,N-diisopropylamino)phosphine and tetraisopropylphosphorodiamidous chloride.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Bis(diisopropylamino)chlorophosphine at an assay of not less than 95.0%, as a research and synthesis grade reagent. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis is provided with each batch, and specific assay or packaging requirements can be discussed at the time of enquiry.
What are the safety and handling requirements for Bis(diisopropylamino)chlorophosphine?
+
It is classified GHS05, signal word Danger, with hazard statement H314 (causes severe skin burns and eye damage), and it reacts violently with water. Handle only under dry, inert conditions away from moisture, using eye and face protection, gloves and appropriate respiratory protection. In case of contact, rinse cautiously with water and seek immediate medical attention. Always consult the Safety Data Sheet before use.
How is Bis(diisopropylamino)chlorophosphine packed, shipped and exported?
+
Because it is moisture-sensitive and corrosive, the product is packed under inert atmosphere in tightly sealed, compatible containers and labelled in accordance with transport regulations. It is classified for transport as UN 3261, Class 8 (corrosive), Packing Group I, and is shipped as dangerous goods with appropriate documentation. Tech Serve Solutions exports worldwide and can tailor pack sizes to your needs.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, intended assay or specification, destination country and any documentation needs. We will respond with availability, packaging options, lead time and the relevant compliance and transport details for this corrosive, moisture-sensitive reagent.
▶ Related products
Benzeneruthenium(II) chloride dimer
Ru2(C6H6)2Cl4
Catalysis & Inorganic
Benzoylferrocene
C17H14FeO
Catalysis & Inorganic
Benzyldiphenylphosphine
C6H5CH2P(C6H5)2
Catalysis & Inorganic
Beryllium
Be
Catalysis & Inorganic
Beryllium oxide
BeO
Catalysis & Inorganic![Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer — chemical structure, CAS 12257-42-0; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F12257-42-0.png&w=3840&q=75)
Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer
Catalysis & Inorganic
![Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo — chemical structure, CAS 1228149-03-8; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1228149-03-8.png&w=3840&q=75)
Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo
1-d:1′
Catalysis & Inorganic![Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (C16H20ClN3Ni) — chemical structure, CAS 1033772-47-2; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1033772-47-2.png&w=3840&q=75)
Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride
C16H20ClN3Ni
Catalysis & Inorganic▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis