Bis(dicyclohexylphosphinophenyl) ether
Bis(dicyclohexylphosphinophenyl) ether (CAS 434336-16-0; C36H52OP2; molar mass 562.75 g/mol) is a bidentate, electron-rich tertiary phosphine ligand built on a diaryl-ether backbone bearing two dicyclohexylphosphino groups. Supplied as a solid of 97% assay, it is used chiefly as a supporting ligand in transition-metal catalysis, including palladium-mediated carbon-nitrogen bond formation such as diastereoselective intramolecular N-arylation and intermolecular carboamination. Tech Serve Solutions supplies it to research and fine-chemical synthesis laboratories worldwide.
- IUPAC
- (Oxydi-2,1-phenylene)bis[dicyclohexyl] phosphine
- Synonyms
- Bis(dicyclohexylphosphinophenyl) ether(Oxydi-2,1-phenylene)bis[dicyclohexyl]phosphine(Oxydi-2,1-phenylene)bis(dicyclohexylphosphine)Bis[(2-dicyclohexylphosphino)phenyl] etherDCyPF ether ligandCAS 434336-16-0
Ligand for palladium-catalysed C-N coupling
Functions as a bidentate phosphine ligand in transition-metal complexes, supporting palladium-catalysed carbon-nitrogen bond-forming reactions. It is documented as a catalyst component for diastereoselective intramolecular N-arylation and intermolecular carboamination.
Diastereoselective amination chemistry
The electron-rich dicyclohexylphosphino donors and wide-bite-angle ether backbone help control reactivity and selectivity in amination reactions, making it useful where diastereocontrol is required.
Synthesis of nitrogen-containing scaffolds
Through its role in carboamination and N-arylation, the ligand assists in constructing heterocyclic and amine-bearing frameworks of interest in pharmaceutical-intermediate and fine-chemical research.
Research and methodology development
As a defined, high-purity phosphine ligand, it serves laboratories investigating new catalytic methods, ligand screening and reaction optimisation in academic and industrial settings.
| Molecular weight | 562.75 |
|---|---|
| Empirical formula | C36H52OP2 |
| Assay | 97% |
| Application | Catalyst for diastereoselective intramolecular N-arylation intermolecular carboamination1 |
| Melting point | 140-146 °C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(dicyclohexylphosphinophenyl) ether used for?
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It is used mainly as a bidentate phosphine ligand in transition-metal catalysis. It is documented as a catalyst component for diastereoselective intramolecular N-arylation and intermolecular carboamination, supporting palladium-mediated carbon-nitrogen bond formation in chemical synthesis.
What is the CAS number and molecular formula of Bis(dicyclohexylphosphinophenyl) ether?
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The CAS number is 434336-16-0 and the empirical formula is C36H52OP2 (Hill notation), corresponding to a molecular weight of 562.75 g/mol. It is also known as (oxydi-2,1-phenylene)bis[dicyclohexyl]phosphine.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(dicyclohexylphosphinophenyl) ether at a typical assay of 97%, as a research/reagent-grade solid with a melting point of approximately 140-146 °C. We do not represent this material as USP, BP or EP grade. A certificate of analysis can be provided on request.
What are the safety and handling considerations?
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The material carries GHS pictogram GHS07 with the signal word Warning. Hazard statements are H302, H312, H315, H319, H332 and H335 - harmful if swallowed, in contact with skin or if inhaled, and causing skin, eye and respiratory irritation. Handle with appropriate protection (P261, P280) in a well-ventilated area, avoid dust generation, and in case of eye contact rinse cautiously (P305+P351+P338). As an air-sensitive phosphine, it is best stored and handled under inert atmosphere. Always consult the Safety Data Sheet before use.
How is Bis(dicyclohexylphosphinophenyl) ether packed, shipped and exported?
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It is supplied in suitably sealed laboratory and bulk packaging appropriate to the order quantity, labelled in line with GHS requirements. As an air-sensitive phosphine it is packed to limit exposure to air and moisture. Tech Serve Solutions exports globally with the relevant documentation, including the Safety Data Sheet and certificate of analysis.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time, documentation and a quotation. Samples can be arranged where appropriate to support evaluation.
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