Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride
Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (CAS 1033772-47-2), commonly known as Nickamine, is a well-defined NN2 pincer nickel(II) complex with the molecular formula C16H20ClN3Ni and a molar mass of 348.50 g/mol. This air-stable organometallic catalyst promotes selective carbon-carbon bond formation, notably the cross-coupling of non-activated alkyl halides. Tech Serve Solutions supplies it as a research-grade catalyst (assay greater than or equal to 97%) for synthetic and catalysis laboratories.
- IUPAC
- Chloro[N2-[2-(dimethylamino-κN)phenyl]-N1,N1-dimethyl-1,2-benzenediaminato-κN1,κN2]-nickel,Nickamine
- Synonyms
- Bis[(2-dimethylamino)phenyl]amine nickel(II) chlorideNickamineChloro[N2-[2-(dimethylamino-kappaN)phenyl]-N1,N1-dimethyl-1,2-benzenediaminato-kappaN1,kappaN2]-nickelNN2 pincer nickel(II) chlorideCAS 1033772-47-2
![Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (C16H20ClN3Ni) — chemical structure, CAS 1033772-47-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1033772-47-2.png&w=3840&q=75)
Kumada-type cross-coupling of alkyl halides
Nickamine catalyses the alkyl-alkyl Kumada coupling of secondary alkyl halides and the Kumada-Corriu-Tamao coupling of non-activated alkyl halides with aryl and heteroaryl Grignard nucleophiles. It enables selective carbon-carbon bond formation at sp3 centres that are challenging for conventional catalysts.
Sonogashira coupling of non-activated alkyl halides
The complex serves as a catalyst for the Sonogashira-type coupling of non-activated alkyl halides with terminal alkynes, providing access to substituted alkynes under nickel catalysis.
Direct C-H alkylation of heterocycles
Nickamine is used for the direct alkylation of heterocyclic C-H bonds, allowing alkyl groups to be installed onto heteroaromatic frameworks without prefunctionalisation.
NN2 pincer ligand-metal reagent
As a defined pincer NN2 nickel reactant, the compound is employed in methodology studies directed at selective carbon-carbon bond formation and in the development of related nickel-catalysed transformations.
Catalysis and inorganic-chemistry research
Supplied as a research-grade organometallic catalyst, it is suitable for reaction-development, screening and reference work in synthetic, catalysis and organometallic laboratories.
| Molecular weight | 348.50 |
|---|---|
| Empirical formula | C16H20ClN3Ni |
| Assay | ≥97% (AT) |
| Application | Catalyst for:• Alkyl-alkyl Kumada coupling of secondary alkyl halides1• Direct alkylation of heterocyclic C-H bonds2• Sonogashira coupling of nonactivated alkyl halides3• Kumada-Corriu-Tamao coupling of nonactivated alkyl halides with aryl and heteroaryl nucleophiles4Reactant of pincer NN2 ligand leading to selective carbon-carbon bond formation5 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride used for?
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It is used as a homogeneous nickel catalyst, widely known as Nickamine, for selective carbon-carbon bond formation. Documented applications include the alkyl-alkyl Kumada coupling of secondary alkyl halides, Kumada-Corriu-Tamao and Sonogashira coupling of non-activated alkyl halides, and the direct alkylation of heterocyclic C-H bonds. It also serves as a defined NN2 pincer nickel reagent in methodology research.
What is the CAS number and molecular formula of Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride?
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The CAS number is 1033772-47-2 and the empirical formula is C16H20ClN3Ni (Hill notation), corresponding to a molecular weight of 348.50 g/mol. It is also catalogued as Nickamine and as chloro[N2-[2-(dimethylamino-kappaN)phenyl]-N1,N1-dimethyl-1,2-benzenediaminato-kappaN1,kappaN2]-nickel.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this catalyst with a typical assay of greater than or equal to 97% (AT), as a research-grade organometallic reagent. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch.
What are the safety and handling requirements?
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Handle as a nickel-containing organometallic compound using gloves, eye protection and adequate ventilation, and avoid the generation of dust. Nickel complexes should be treated as potential sensitisers and handled by trained personnel under good laboratory practice. The water-hazard class is WGK (Germany) 3, the most hazardous category, so prevent any release to drains, soil or waterways. Please consult the supplied safety data sheet before use.
How is Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized from research quantities to larger orders, with full hazard labelling and documentation. As a global supplier and exporter, Tech Serve Solutions arranges compliant international shipment accompanied by a certificate of analysis and safety data sheet; pack sizes can be tailored to your requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, documentation and a quotation. Samples can be arranged for qualification, subject to standard order terms.
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