Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride
Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride (CAS 945375-77-9), abbreviated (A-caPhos)2PdCl2, is a homogeneous palladium(II) pre-catalyst bearing two electron-rich dicyclohexyl(4-dimethylaminophenyl)phosphine (A-caPhos) ligands. Its linear formula is (CH3)2NC6H4P(C6H11)2PdCl2P(C6H4N(CH3)2)(C6H11)2, with a molar mass of approximately 812 g/mol. As a non-proprietary phosphine-ligated complex, it is used principally as a defined catalyst for palladium-catalysed carbon-carbon and carbon-heteroatom cross-coupling reactions in fine-chemical, pharmaceutical-intermediate and methodology research and synthesis.
- IUPAC
- (A-caPhos)2 PdCl2
- Synonyms
- Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride(A-caPhos)2PdCl2Bis(di-cyclohexyl(4-dimethylaminophenyl)phosphine)palladium(II) dichlorideDichlorobis[dicyclohexyl(4-dimethylaminophenyl)phosphine]palladium(II)A-caPhos palladium(II) chlorideCAS 945375-77-9
![Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride ((CH3)2NC6H4P(C6H11)2PdCl2P(C6H4N(CH3)2)(C6H11)2) — chemical structure, CAS 945375-77-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F945375-77-9.png&w=3840&q=75)
Cross-coupling catalysis
Serves as a defined homogeneous palladium(II) pre-catalyst for carbon-carbon and carbon-heteroatom bond-forming cross-couplings, including Suzuki-Miyaura, Negishi and related reactions. The electron-rich, sterically demanding A-caPhos ligands promote oxidative addition and stabilise the active palladium(0) species.
Pharmaceutical and fine-chemical synthesis
Applied in the construction of complex molecular scaffolds and intermediates where reliable, reproducible catalyst performance is required. Its well-defined ligand-to-metal ratio supports consistent results across research and process chemistry.
Ligand-accelerated coupling of demanding substrates
The strongly donating dimethylamino-substituted aryl phosphine framework assists couplings involving less reactive or hindered partners. This makes the complex a useful option when simpler palladium sources give incomplete conversion.
Research and method development
Used in laboratory-scale catalyst screening and reaction optimisation as a non-proprietary, structurally defined alternative to in-situ palladium/phosphine mixtures. It provides a single, characterised catalyst for benchmarking and methodology studies.
| Linear formula | (CH3)2NC6H4P(C6H11)2PdCl2P(C6H4N(CH3)2)(C6H11)2 |
|---|
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride used for?
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It is used as a homogeneous palladium(II) pre-catalyst for palladium-catalysed cross-coupling reactions, such as Suzuki-Miyaura and other carbon-carbon and carbon-heteroatom bond-forming couplings. Its electron-rich A-caPhos ligands make it suitable for fine-chemical, pharmaceutical-intermediate and methodology research where a defined, reproducible catalyst is needed.
What is the CAS number and molecular formula of Bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine] palladium(II) chloride?
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The CAS number is 945375-77-9. Its linear formula is (CH3)2NC6H4P(C6H11)2PdCl2P(C6H4N(CH3)2)(C6H11)2, with a molar mass of approximately 812 g/mol. It is commonly abbreviated as (A-caPhos)2PdCl2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this palladium complex as a research and synthesis-grade catalyst, with specifications confirmed against the batch certificate of analysis. We do not represent it as a USP, BP or EP pharmacopoeial grade. Exact assay and lot details are provided on request and on the accompanying documentation.
What are the safety and handling requirements for this material?
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It is classified under GHS07 with the signal word Warning and the hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and a suitable N95-type dust mask, avoid dust generation, and follow the precautionary advice P261 and P305+P351+P338. It carries German Water Hazard Class WGK 3, so prevent release to drains and watercourses. Always consult the Safety Data Sheet before use.
How is this palladium catalyst packed, shipped and exported?
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It is packed in tightly sealed, appropriately labelled containers sized to the order, with full documentation including the certificate of analysis and Safety Data Sheet. Tech Serve Solutions arranges compliant export shipping worldwide in line with applicable transport and customs regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, quoting CAS 945375-77-9. We will respond with availability, lead time, documentation and a formal quotation, and can arrange samples where appropriate.
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