Bis(diethylamino)chlorophosphine
Bis(diethylamino)chlorophosphine (CAS 685-83-6; formula [(C2H5)2N]2PCl; molar mass 210.68 g/mol) is a colourless, moisture-sensitive trivalent phosphorus reagent bearing two diethylamino groups and a reactive P-Cl bond. It is widely used as a phosphorylating building block in organophosphorus synthesis, providing a route to phosphoramidites, aminophosphines and related P(III) ligands. Tech Serve Solutions supplies it at 97% assay for research and manufacturing. It reacts violently with water and is corrosive.
- Synonyms
- Bis(diethylamino)chlorophosphineChlorobis(diethylamino)phosphineN,N,N',N'-Tetraethylphosphorodiamidous chlorideBis(diethylamino)phosphorus chlorideChloro-bis(diethylamino)phosphine[(C2H5)2N]2PCl
![Bis(diethylamino)chlorophosphine ([(C2H5)2N]2PCl) — chemical structure, CAS 685-83-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F685-83-6.png&w=3840&q=75)
Phosphoramidite and aminophosphine synthesis
The reactive P-Cl bond is readily displaced by alcohols, amines and other nucleophiles, making this reagent a convenient way to install the bis(diethylamino)phosphino moiety. It is a common precursor in the preparation of phosphoramidite and aminophosphine derivatives.
P(III) ligand and precursor chemistry
As a trivalent phosphorus precursor, it serves in the construction of phosphorus-containing ligands and intermediates used in coordination chemistry and homogeneous catalysis research.
General phosphorylation reagent
It is used to introduce a diaminochlorophosphine functionality onto substrates in organophosphorus chemistry, typically under anhydrous, inert conditions with a base to scavenge the liberated hydrogen chloride.
Research and laboratory reagent
Supplied as a reagent-grade material, it supports method development and exploratory synthesis in academic and industrial laboratories working with phosphorus chemistry.
| Molecular weight | 210.68 |
|---|---|
| Linear formula | [(C2H5)2N]2PCl |
| Assay | 97% |
| Boiling point | 55-57 °C/0.2 mmHg(lit.) |
| Density | 1.002 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4895(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 23-26-36-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(diethylamino)chlorophosphine used for?
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It is used primarily as a phosphorylating reagent and trivalent phosphorus building block in organophosphorus synthesis. Its reactive P-Cl bond allows the bis(diethylamino)phosphino group to be transferred to alcohols, amines and other nucleophiles, giving phosphoramidites, aminophosphines and related P(III) compounds and ligands.
What is the CAS number and molecular formula of Bis(diethylamino)chlorophosphine?
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The CAS number is 685-83-6 and the molecular formula is [(C2H5)2N]2PCl, with a molecular weight of 210.68 g/mol. The MDL number is MFCD00015493 and the PubChem Substance ID is 24862321.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(diethylamino)chlorophosphine at a typical assay of 97% as a research and laboratory reagent grade. We do not represent it as a USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch; please confirm your specification when enquiring.
What are the safety and handling hazards of Bis(diethylamino)chlorophosphine?
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It is classified GHS05, signal word Danger, and causes severe skin burns and eye damage (H314). It reacts violently with water. Handle only under dry, inert conditions with appropriate ventilation, wearing gloves, goggles and a faceshield, and use suitable respiratory protection. In case of contact with eyes, rinse cautiously and seek immediate medical advice. Keep away from moisture and incompatible materials.
How is Bis(diethylamino)chlorophosphine packed, shipped and exported?
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Because it is moisture-sensitive and corrosive, it is packed in tightly sealed, inert containers appropriate to the order quantity and labelled in line with its transport classification, UN 3265, Class 8, Packing Group II. It is shipped as dangerous goods with the required documentation. As a global exporter, Tech Serve Solutions arranges compliant international dispatch.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, target specification and destination, and our team will respond with availability, lead time and export details. Sample availability can be confirmed on enquiry for qualified applications.
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