Bis(2-methoxyphenyl)chlorophosphine
Bis(2-methoxyphenyl)chlorophosphine (CAS 263369-88-6) is an air- and moisture-sensitive organophosphorus chlorophosphine with the molecular formula C14H14ClO2P and a molecular weight of 280.69 g/mol. The reactive P–Cl bond makes it a versatile building block for preparing tertiary phosphine ligands. It is used in asymmetric catalysis and chemical synthesis, including cycloadditions, asymmetric hydrogenation and the construction of ferrocene-based chiral diphosphines and palladium complexes. Tech Serve Solutions supplies it as a research-grade reagent.
- Synonyms
- Bis(2-methoxyphenyl)chlorophosphineChlorobis(2-methoxyphenyl)phosphineBis(2-methoxyphenyl)phosphinous chlorideBis(o-methoxyphenyl)chlorophosphineCAS 263369-88-6MFCD08064037
Phosphine ligand precursor
The reactive phosphorus–chlorine bond allows ready substitution to build tertiary phosphine ligands. It is a recognised reactant for the synthesis of ferrocene-based chiral diphosphines used in asymmetric catalysis.
Asymmetric hydrogenation and allylic substitution
Ligands derived from this chlorophosphine are applied in asymmetric hydrogenation and allylic substitution, including the asymmetric hydrogenation of imines and olefins.
Cross-coupling and palladium complexes
It serves as a reactant in the preparation of catalysts for carbon–carbon cross-coupling reactions and in the synthesis of palladium complexes used in modern synthetic chemistry.
Cycloaddition chemistry
The compound is documented as a reactant for cycloaddition reactions, supporting the assembly of more complex phosphorus-containing or carbocyclic frameworks.
Research and method development
As a defined organophosphorus reagent of 95% assay, it is suited to laboratory-scale catalysis research, ligand design and process-development studies.
| Molecular weight | 280.69 |
|---|---|
| Empirical formula | C14H14ClO2P |
| Assay | 95% |
| Application | Reactant for:• Cycloadditions reactions1• Asymmetric hydrogenation and allylic substitution2• Asymmetric hydrogenation of imines and olefins3Reactant for synthesis of:• Ferrocene-based chiral diphosphine4• Catalysts for C-C cross coupling reactions5• Palladium complexes6 |
| Melting point | 109-113 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 1759 8 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(2-methoxyphenyl)chlorophosphine used for?
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It is used in catalysis and chemical synthesis as a precursor to tertiary phosphine ligands. Documented uses include cycloadditions, asymmetric hydrogenation and allylic substitution, asymmetric hydrogenation of imines and olefins, and the synthesis of ferrocene-based chiral diphosphines, cross-coupling catalysts and palladium complexes.
What is the CAS number and molecular formula of Bis(2-methoxyphenyl)chlorophosphine?
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The CAS number is 263369-88-6 and the molecular formula is C14H14ClO2P, with a molecular weight of 280.69 g/mol. The MDL number is MFCD08064037 and the melting point is 109–113 °C.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(2-methoxyphenyl)chlorophosphine at a typical assay of 95% as a research and laboratory-grade reagent. We do not represent it as USP, BP or EP pharmacopoeia grade. A Certificate of Analysis is provided with each consignment.
What are the safety and handling hazards?
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It is classified GHS05, signal word Danger, with hazard statement H314 (causes severe skin burns and eye damage), and it reacts violently with water. Handle under dry, inert conditions away from moisture, wear protective gloves, clothing and eye/face protection, and consult the Safety Data Sheet before use.
How is Bis(2-methoxyphenyl)chlorophosphine packed, shipped and exported?
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It is packed in tightly sealed, moisture-excluding containers appropriate to the order quantity. As a corrosive substance it is classified for transport under UN 1759, Class 8, Packing Group III, and is shipped with full documentation in line with applicable dangerous-goods regulations for export.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and documentation. We support both research-scale samples and larger commercial orders for global export.
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