Bis(2-isopropoxyphenyl)chlorophosphine
Bis(2-isopropoxyphenyl)chlorophosphine (CAS 1219589-19-1) is an organophosphorus(III) building block with the molecular formula C18H22ClO2P and a molar mass of 336.79 g/mol. It is a low-melting solid (m.p. 53-56 °C) bearing a reactive P-Cl bond flanked by two ortho-isopropoxy-substituted aryl groups. This chlorophosphine serves chiefly as an intermediate and precursor for preparing tertiary phosphine ligands used in transition-metal catalysis and fine-chemical synthesis.
- Synonyms
- Bis(2-isopropoxyphenyl)chlorophosphineChlorobis(2-isopropoxyphenyl)phosphineBis(2-isopropoxyphenyl)phosphinous chlorideBis[2-(propan-2-yloxy)phenyl]phosphinous chlorideCAS 1219589-19-1
Phosphine ligand synthesis
The reactive P-Cl bond is readily displaced by carbon, nitrogen or oxygen nucleophiles, making the compound a versatile precursor to tertiary phosphines. Such phosphines are widely employed as supporting ligands in homogeneous transition-metal catalysis.
Organophosphorus intermediate
It functions as a phosphorylating reagent for installing the diarylphosphino unit into more elaborate molecules. The ortho-isopropoxy aryl substituents impart defined steric and electronic character to the resulting phosphorus centre.
Catalysis research and development
As a phosphorus(III) precursor, it supports the design and screening of new ligand frameworks for cross-coupling and related catalytic transformations. It is supplied for laboratory research and process-development use.
Fine-chemical and pharmaceutical synthesis
Phosphine ligands derived from chlorophosphines underpin metal-catalysed steps used in the manufacture of fine chemicals and pharmaceutical intermediates. This reagent provides a route to such ligand systems at research and pilot scale.
| Molecular weight | 336.79 |
|---|---|
| Empirical formula | C18H22ClO2P |
| Assay | 97% |
| Melting point | 53-56 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 3261 8 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(2-isopropoxyphenyl)chlorophosphine used for?
+
It is used primarily as an organophosphorus building block and precursor for synthesising tertiary phosphine ligands. These ligands support transition-metal catalysis and are applied across fine-chemical and pharmaceutical intermediate synthesis. Its reactive P-Cl bond allows the diarylphosphino group to be transferred to other molecules.
What is the CAS number and molecular formula of Bis(2-isopropoxyphenyl)chlorophosphine?
+
The CAS number is 1219589-19-1 and the molecular formula is C18H22ClO2P, corresponding to a molecular weight of 336.79 g/mol. It is a solid with a melting point of approximately 53-56 °C.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this material at a typical assay of 97%, as a technical/research grade reagent for synthesis and catalysis applications. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided with each batch on request.
What are the safety and handling hazards of Bis(2-isopropoxyphenyl)chlorophosphine?
+
It is classified under GHS with the signal word Danger and hazard statement H314: causes severe skin burns and eye damage. It is corrosive and moisture-sensitive, reacting with water to release hydrogen chloride. Handle under inert, dry conditions with suitable protective gloves, eye/face protection and ventilation (P280, P305+P351+P338, P310), and consult the Safety Data Sheet before use.
How is Bis(2-isopropoxyphenyl)chlorophosphine packed, shipped and exported?
+
It is packed in tightly sealed, moisture-excluding containers appropriate to the order quantity and labelled to GHS requirements. For transport it is classified as a corrosive substance, UN 3261, Class 8, Packing Group II. Tech Serve Solutions exports worldwide with full documentation, observing applicable dangerous-goods regulations.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, purity and packing specification, and we will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation where permitted, accompanied by the Safety Data Sheet and certificate of analysis.
▶ Related products
Benzeneruthenium(II) chloride dimer
Ru2(C6H6)2Cl4
Catalysis & Inorganic
Benzoylferrocene
C17H14FeO
Catalysis & Inorganic
Benzyldiphenylphosphine
C6H5CH2P(C6H5)2
Catalysis & Inorganic
Beryllium
Be
Catalysis & Inorganic
Beryllium oxide
BeO
Catalysis & Inorganic![Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer — chemical structure, CAS 12257-42-0; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F12257-42-0.png&w=3840&q=75)
Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer
Catalysis & Inorganic
![Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo — chemical structure, CAS 1228149-03-8; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1228149-03-8.png&w=3840&q=75)
Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo
1-d:1′
Catalysis & Inorganic![Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (C16H20ClN3Ni) — chemical structure, CAS 1033772-47-2; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1033772-47-2.png&w=3840&q=75)
Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride
C16H20ClN3Ni
Catalysis & Inorganic▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis