4-Hydroxy-TEMPO
4-Hydroxy-TEMPO (CAS 2226-96-2), with the molecular formula C9H18NO2 and a molecular weight of 172.24 g/mol, is a stable nitroxide radical. It serves as a valuable spin label reagent in biochemical studies, particularly for characterising receptor binding sites. This compound also finds application in measuring reactive oxygen generation in cardiac muscle tissue via electron spin resonance spectroscopy and can offer protection against certain cellular damage.
- IUPAC
- 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl,TEMPOL
- Synonyms
- TEMPOL
Spin Labelling Reagent
Used in the characterisation of antagonist and agonist binding sites of the NK1 receptor. It facilitates the study of receptor-ligand interactions through electron spin resonance techniques.
Reactive Oxygen Species Measurement
Applicable for measuring reactive oxygen generation in cardiac muscle by electron spin resonance spectroscopy. This aids in understanding oxidative stress in biological systems.
Cellular Protection
TEMPOL can protect cells overexpressing CYP2E1 from toxicity damage induced by arachidonic acid. This highlights its potential in mitigating specific cellular injuries.
Synthetic Chemistry
As a stable radical and derivative of TEMPO, it is employed in various organic synthesis applications, leveraging its unique radical properties.
| Molecular weight | 172.24 |
|---|---|
| Empirical formula | C9H18NO2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | Spin label reagent used in the chatacterization of antagonist and agonist binding sites of NK1 receptor. Also used to measure reactive oxygen generation in heart muscle by electron spin resonance spectroscopy. Cells that overexpress CYP2E1 can be protected from arachidonic acid toxicity damage by TEMPOL. |
| Melting point | 69-71 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxy-TEMPO used for?
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4-Hydroxy-TEMPO is used as a spin label reagent for characterising receptor binding sites, measuring reactive oxygen generation in heart muscle, and protecting cells from certain toxic damage. It is also used in chemical synthesis and radical chemistry.
What is the CAS number and molecular formula for 4-Hydroxy-TEMPO?
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The CAS number for 4-Hydroxy-TEMPO is 2226-96-2, and its empirical formula is C9H18NO2.
What grade and purity does Tech Serve Solutions supply for 4-Hydroxy-TEMPO?
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Tech Serve Solutions supplies 4-Hydroxy-TEMPO with a minimum purity of 97% (assay). This is considered a research or technical grade; TSS does not represent it as USP, BP, or EP.
How should 4-Hydroxy-TEMPO be handled safely?
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4-Hydroxy-TEMPO is classified as a Warning substance. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
How is 4-Hydroxy-TEMPO packed and shipped?
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4-Hydroxy-TEMPO is typically stored at 2-8°C. TSS exports chemicals globally, adhering to all necessary shipping regulations for chemical compounds.
How can I request a quote or sample for 4-Hydroxy-TEMPO?
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To request a quote or sample, please contact our sales team through the website or by phone. Provide the product name (4-Hydroxy-TEMPO) and CAS number (2226-96-2) in your inquiry.
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