4-Hydroxy-D-phenylglycine
4-Hydroxy-D-phenylglycine (CAS: 22818-40-2), a derivative of phenylglycine with the linear formula HOC6H4CH(NH2)CO2H and a molecular weight of 167.16 g/mol, is a key intermediate in chemical synthesis and peptide chemistry. It is widely recognised for its role in the construction of unnatural amino acid derivatives and is valuable in chemical biology research. This compound is supplied by Tech Serve Solutions for laboratory and research applications.
- IUPAC
- (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid

Peptide Synthesis
4-Hydroxy-D-phenylglycine serves as an essential building block in the synthesis of peptides, particularly those incorporating unnatural amino acid residues to modify biological activity or stability.
Chemical Biology Research
This unnatural amino acid derivative is employed in chemical biology to investigate protein structure-function relationships and to develop novel biomolecules with tailored properties.
Organic Synthesis Intermediate
As a versatile intermediate, it facilitates the creation of complex organic molecules, contributing to advancements in medicinal chemistry and materials science.
| Molecular weight | 167.16 |
|---|---|
| Linear formula | HOC6H4CH(NH2)CO2H |
| Assay | ≥98% |
| Optical activity | [α]23/D −158±3°, c = 1 in 1 M HCl |
| Melting point | 240 °C (dec.)(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxy-D-phenylglycine used for?
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4-Hydroxy-D-phenylglycine is used in peptide chemistry, chemical synthesis, chemical biology research, and for creating unnatural amino acid derivatives.
What are the CAS number and chemical formula for 4-Hydroxy-D-phenylglycine?
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The CAS number is 22818-40-2 and the linear chemical formula is HOC6H4CH(NH2)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Hydroxy-D-phenylglycine with an assay of ≥98%. This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.
What are the safety considerations when handling 4-Hydroxy-D-phenylglycine?
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4-Hydroxy-D-phenylglycine is classified with GHS07, a Warning signal word, and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid dust formation.
How is 4-Hydroxy-D-phenylglycine packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions professionally packs, ships, and exports 4-Hydroxy-D-phenylglycine worldwide, adhering to all relevant shipping regulations for chemical substances.
How can I request a sample or quote for 4-Hydroxy-D-phenylglycine?
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To request a sample or a quotation, please contact our sales department via the website or direct email, providing your specific requirements and delivery details.
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