4-(Trifluoromethyl)-L-phenylalanine
4-(Trifluoromethyl)-L-phenylalanine (CAS: 114926-38-4), a non-proteinogenic amino acid derivative with the molecular formula C10H10F3NO2 and a molecular weight of 233.19 g/mol, is a valuable building block in chemical synthesis. Its unique trifluoromethyl substitution on the phenyl ring offers distinct electronic properties. It is primarily employed in research and development settings for the synthesis of novel compounds, particularly in peptide chemistry and the exploration of chemical biology.
- IUPAC
- (S)-2-Amino-3-[4-(trifluoromethyl)phenyl]propionic acid

Peptide Synthesis
Incorporated into peptide chains to introduce the trifluoromethylphenyl moiety, allowing for modulation of physicochemical properties and biological activity in research peptides.
Chemical Biology Research
Utilised as a tool compound or building block for creating labelled molecules or probes to study biological processes and protein function.
Drug Discovery and Development
Serves as an intermediate or key component in the synthesis of potential pharmaceutical candidates, leveraging the influence of the trifluoromethyl group on metabolic stability and binding affinity.
Material Science
Can be explored in the development of novel materials where its specific electronic and structural characteristics are advantageous.
| Molecular weight | 233.19 |
|---|---|
| Empirical formula | C10H10F3NO2 |
| Assay | ≥99.0% |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)-L-phenylalanine used for?
+
4-(Trifluoromethyl)-L-phenylalanine is primarily used as a building block in chemical synthesis, particularly in peptide chemistry and chemical biology research, for creating novel compounds and exploring their biological activities.
What is the CAS number and molecular formula for 4-(Trifluoromethyl)-L-phenylalanine?
+
The CAS number is 114926-38-4 and the molecular formula is C10H10F3NO2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4-(Trifluoromethyl)-L-phenylalanine with an assay of ≥99.0%. This product is supplied for research and development purposes and is not intended for USP, BP, EP, or other pharmacopoeia grades.
How should 4-(Trifluoromethyl)-L-phenylalanine be handled?
+
Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. The compound is classified under WGK 3 in Germany, indicating a high hazard to water.
Is 4-(Trifluoromethyl)-L-phenylalanine a controlled substance?
+
The provided data does not indicate that 4-(Trifluoromethyl)-L-phenylalanine is a controlled substance.
How is 4-(Trifluoromethyl)-L-phenylalanine packed and shipped?
+
As a specialist global supplier and exporter, Tech Serve Solutions ensures appropriate packaging and adherence to international shipping regulations for all its chemical products.
How can I request a sample or quote for 4-(Trifluoromethyl)-L-phenylalanine?
+
You can request a sample or obtain a quote by contacting our sales team directly through the TSS website or by calling our customer service line.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis