Ethyldiphenylphosphine oxide
Ethyldiphenylphosphine oxide (CAS: 1733-57-9), with the molecular formula C2H5P(C6H5)2(O) and a molecular weight of 230.24, is a phosphine oxide compound. It serves as a valuable reactant in various organic synthesis pathways. Key applications include regioselective lactonization reactions, the synthesis of advanced catalytic materials, and as a participant in nucleophilic aromatic substitution reactions. Its utility extends to stereospecific reductions and the formation of phosphines.
- IUPAC
- Diphenylphosphinoethane monoxide
Regioselective Lactonization
Ethyldiphenylphosphine oxide acts as a reactant in the regioselective lactonization of unsymmetrical 1,4-diols. This application is crucial for the synthesis of specific cyclic ester compounds.
Synthesis of Molybdenum Catalysts
This compound is employed in the synthesis of nanostructured dioxomolybdenum(VI) catalysts. These catalysts are specifically designed for the liquid-phase epoxidation of olefins, a significant process in industrial chemistry.
Reduction of Phosphine Oxides
Ethyldiphenylphosphine oxide can be reduced using DIBAL-H, leading to the formation of tertiary phosphines. This is a key transformation for accessing different classes of organophosphorus compounds.
Nucleophilic Aromatic Substitution
It participates in nucleophilic aromatic substitution of hydrogen, facilitated by phosphorous-stabilised carbanions. This method allows for the introduction of phosphorous-containing groups onto aromatic rings.
Stereospecific Reduction to Phosphines
The compound undergoes stereospecific reduction to yield phosphines, a process vital for maintaining stereochemical integrity in complex syntheses.
| Molecular weight | 230.24 |
|---|---|
| Linear formula | C2H5P(C6H5)2(O) |
| Assay | 97% |
| Application | Reactant for:• Regioselective lactonization of unsymmetrical 1,4-diols1• Synthesis of a nanostructured dioxomolybdenum(VI) catalyst for liquid-phase epoxidation of olefins2• Reduction of tertiary phosphine oxides with DIBAL-H3• Diphenylphosphineyl-mediated synthesis of ketones4• Nucleophilic aromatic substitution of hydrogen by phosphorous stabilized carbanions5• Stereospecific reduction to form phosphines6 |
| Melting point | 120-125 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyldiphenylphosphine oxide used for?
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Ethyldiphenylphosphine oxide (CAS: 1733-57-9) is used as a reactant in regioselective lactonization of unsymmetrical 1,4-diols, synthesis of dioxomolybdenum(VI) catalysts for olefin epoxidation, reduction of tertiary phosphine oxides, diphenylphosphineyl-mediated synthesis of ketones, nucleophilic aromatic substitution, and stereospecific reduction to form phosphines.
What are the CAS number and molecular formula for Ethyldiphenylphosphine oxide?
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The CAS number is 1733-57-9 and the molecular formula is C2H5P(C6H5)2(O).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyldiphenylphosphine oxide with an assay of 97%. This product is not classified as USP, BP, or EP grade.
How should Ethyldiphenylphosphine oxide be handled safely?
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Ethyldiphenylphosphine oxide is harmful if swallowed, causes skin irritation, and causes serious eye irritation and may cause respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, in a well-ventilated area.
Is Ethyldiphenylphosphine oxide a controlled substance?
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The provided data does not indicate that Ethyldiphenylphosphine oxide is a controlled substance.
How is Ethyldiphenylphosphine oxide packed and exported?
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Tech Serve Solutions, a global supplier and exporter, ensures appropriate packaging for Ethyldiphenylphosphine oxide for safe transit and adherence to international shipping regulations.
How can I request a quote or sample for Ethyldiphenylphosphine oxide?
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To request a quote or sample for Ethyldiphenylphosphine oxide, please contact our sales team through the TSS website or designated contact channels.
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