Ethyldiphenylphosphine

CAS 607-01-2(C6H5)2PCH2CH3Catalysis & Inorganic

Ethyldiphenylphosphine (CAS: 607-01-2), with the linear formula (C₆H₅)₂PCH₂CH₃ and a molecular weight of 214.24 g/mol, is a phosphine compound widely employed as a ligand and catalyst in organic synthesis. Its applications span diverse catalytic processes, including coupling reactions, cycloadditions, and hydroformylation, contributing to the efficient formation of complex molecules in academic research and industrial chemical synthesis.

IUPAC: Diphenylethylphosphine,NSC 151254
Synonyms: Diphenylethylphosphine

Email us

Ethyldiphenylphosphine ((C6H5)2PCH2CH3) — chemical structure, CAS 607-01-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphine Ligands

01 /Applications

Catalysis in Organic Synthesis

Ethyldiphenylphosphine serves as a valuable catalyst and ligand in various organic transformations. It facilitates three-component coupling reactions of arylaldehydes with methyl vinyl ketone and phthalimide, and is instrumental in the regio- and stereoselective hydroalkynylation of methylenecyclopropanes.

Heterocycle Synthesis

This compound is employed in the synthesis of important heterocyclic structures. Its catalytic activity aids in the formation of oxazolidines, thiazolidines, pyrrolidines, and indoles, which are common motifs in pharmaceuticals and biologically active molecules.

Advanced Catalytic Processes

Ethyldiphenylphosphine participates in more complex catalytic cycles, such as tandem Morita-Baylis-Hillman/Michael addition reactions. It is also utilized in platinum-catalyzed cyclization and intermolecular hydroamination reactions, demonstrating its versatility.

Hydroformylation Reactions

The compound acts as a ligand in hydroformylation reactions, a critical industrial process for converting alkenes into aldehydes. This application highlights its utility in large-scale chemical manufacturing and fine chemical production.

02 /Properties

Molecular weight	214.24
Linear formula	(C6H5)2PCH2CH3
Assay	98%
Boiling point	293 °C(lit.)
Density	1.048 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.614(lit.)
Application	Catalyst for:• Three component coupling reactions of arylaldehydes with Me vinyl ketone and phthalimide1• Regio- and stereoselective hydroalkynylation of methylenecyclopropanes2• Synthesis of oxazolidines, thiazolidines, pyrrolidines, and indoles3• Dimer to monomer conversion4• Tandem Morita-Baylis-Hillman/Michael addition reactions5• Platinum-catalyzed cyclization6• Regioselective and stereoselective [3+2] cycloaddition7• Platinum-catalyzed intermolecular hydroamination8• Hydroformylation reactions9

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	110 °C / 230 °F
Transport (UN / ADR)	UN 3334
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

607-01-2

MDL number

MFCD00015170

PubChem substance

24860439

Beilstein registry

744253

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Ethyldiphenylphosphine (CAS: 607-01-2) used for?

Ethyldiphenylphosphine (CAS: 607-01-2) is primarily used as a catalyst and ligand in various organic synthesis reactions, including coupling reactions, hydroalkynylation, heterocycle synthesis, and hydroformylation. It is a key component in advanced catalytic processes.

What are the CAS number and molecular formula for Ethyldiphenylphosphine?

The CAS number for Ethyldiphenylphosphine is 607-01-2, and its linear molecular formula is (C₆H₅)₂PCH₂CH₃.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Ethyldiphenylphosphine with an assay of 98%. This product is supplied for research and development purposes; TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.

How should Ethyldiphenylphosphine be handled safely?

Ethyldiphenylphosphine is classified as harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation and avoid inhalation of vapours or dust.

How is Ethyldiphenylphosphine packed, shipped, and exported?

Ethyldiphenylphosphine is carefully packed according to international shipping regulations for hazardous materials (UN 3334). Tech Serve Solutions, as a specialist global supplier and exporter, ensures compliant packaging and shipment for both domestic and international clients.

How can I request a sample or quote for Ethyldiphenylphosphine?

To request a sample or a quote for Ethyldiphenylphosphine, please visit the Tech Serve Solutions website or contact our sales department directly. Our team will be pleased to assist you with your specific requirements.