4-(Trifluoromethyl)-L-phenylglycine
4-(Trifluoromethyl)-L-phenylglycine (CAS: 144789-75-3) is a chiral unnatural amino acid derivative with the molecular formula C9H8F3NO2 and a molecular weight of 219.16 g/mol. It serves as a valuable building block in chemical synthesis, particularly within chemical biology and peptide chemistry. Its unique trifluoromethyl group imparts specific properties, making it useful for creating novel molecules and modified peptides.
- IUPAC
- (S)-2-Amino-2-[4-(trifluoromethyl)phenyl]acetic acid
Chiral Building Block
Utilised as a chiral synthon in asymmetric synthesis for the construction of complex organic molecules. The trifluoromethyl moiety can influence electronic and lipophilic properties of the target compound.
Peptide Modification
Incorporated into peptide sequences to create unnatural peptides with altered biological activity, stability, or receptor binding properties. It is particularly useful in peptidomimetics research.
Chemical Biology Research
Employed in studies investigating structure-activity relationships and developing new biochemical probes. The presence of fluorine can aid in NMR studies or improve metabolic stability.
Drug Discovery Intermediate
Serves as an intermediate in the synthesis of potential pharmaceutical candidates. The trifluoromethylphenylglycine scaffold is found in various biologically active compounds.
| Molecular weight | 219.16 |
|---|---|
| Empirical formula | C9H8F3NO2 |
| Assay | ≥98.0% |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethyl)-L-phenylglycine used for?
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4-(Trifluoromethyl)-L-phenylglycine is primarily used as a chiral building block in chemical synthesis, for modifying peptides, in chemical biology research, and as an intermediate in drug discovery.
What are the CAS number and formula for 4-(Trifluoromethyl)-L-phenylglycine?
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The CAS number is 144789-75-3 and the molecular formula is C9H8F3NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethyl)-L-phenylglycine with an assay of ≥98.0%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or other pharmacopoeia grades.
How should 4-(Trifluoromethyl)-L-phenylglycine be handled?
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Handling requires appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Avoid breathing dust. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice if irritation persists. Ensure adequate ventilation.
Can you export 4-(Trifluoromethyl)-L-phenylglycine?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Trifluoromethyl)-L-phenylglycine, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or sample, please visit the Tech Serve Solutions website or contact our sales department directly with your specific requirements.
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