Acycloguanosine
Acycloguanosine (CAS: 59277-89-3, C8H11N5O3) is a white powder with a molecular weight of 225.20 g/mol. This compound is recognised for its role in antiviral research, specifically in studying the latency and reactivation of herpes simplex virus and the reproduction of HIV. It has also been investigated for its mechanism in inhibiting cytomegalovirus replication, independent of thymidine kinase phosphorylation. It is supplied by TSS with an assay of ≥99% by HPLC.
- IUPAC
- 9-[(2-Hydroxyethoxy)methyl]guanine,Acyclovir
- Synonyms
- 9-[(2-Hydroxyethoxy)methyl]guanine,Acyclovir
Antiviral Research
Acycloguanosine is utilised in scientific investigations into the mechanisms of viral replication. It has been employed to study herpes simplex virus latency and reactivation processes. Furthermore, its role in inhibiting cytomegalovirus reproduction, even in the absence of viral or cellular thymidine kinase, makes it a valuable research tool.
HIV Reproduction Studies
This compound serves as a reagent in research focused on understanding and potentially disrupting the reproductive cycle of retroviruses, including HIV. Its application aids in exploring novel therapeutic strategies against viral infections.
Cell Biology Research
As a bioactive small molecule, Acycloguanosine finds application in broader cell biology studies. It can be used to investigate cellular responses to antiviral agents and mechanisms of drug resistance.
| Molecular weight | 225.20 |
|---|---|
| Empirical formula | C8H11N5O3 |
| Assay | ≥99% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | H2O: soluble0.7 mg/mL1 M HCl: soluble50 mg/mLDMSO: soluble7 mg/mL |
| Application | Acycloguanosine has been used to study herpes simplex virus latency and reactivation, as well as HIV retrovirus reproduction. Acycloguanosine inhibits replication of cytomegalovirus by a mechanism that is independent of its phosphorylation by viral or cellular thymidine kinase. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HV1S(3365), NP(4860) |
|---|---|
| Absorption | ε1mM/256 nm 11.8 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Acycloguanosine used for?
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Acycloguanosine is used in research to study herpes simplex virus latency and reactivation, HIV retrovirus reproduction, and cytomegalovirus replication. It is also employed in broader cell biology and antiviral research.
What are the CAS number and chemical formula for Acycloguanosine?
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The CAS number for Acycloguanosine is 59277-89-3, and its chemical formula is C8H11N5O3.
What grade and purity does Tech Serve Solutions supply for Acycloguanosine?
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Tech Serve Solutions supplies Acycloguanosine with a purity of ≥99% as determined by HPLC. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety precautions when handling Acycloguanosine?
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When handling Acycloguanosine, it is advised to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used.
How is Acycloguanosine packaged and shipped?
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Acycloguanosine is available as a white powder. TSS is a global supplier and exporter of fine chemicals and reagents, adhering to all necessary shipping and handling regulations.
How can I request a quote or sample of Acycloguanosine?
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To request a quote or a sample of Acycloguanosine, please contact the Tech Serve Solutions sales team through our website or by phone.
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