4-(Difluoromethoxy)benzenesulfonyl chloride
4-(Difluoromethoxy)benzenesulfonyl chloride (CAS: 351003-34-4) is a fluorinated organic building block with the linear formula F₂CHOC₆H₄SO₂Cl and a molecular weight of 242.63 g/mol. This compound serves as a versatile intermediate in organic synthesis, particularly for introducing the difluoromethoxybenzenesulfonyl moiety into various molecular structures. Its reactivity makes it valuable in the development of novel pharmaceuticals and agrochemicals.
Organic Synthesis Intermediate
Utilised as a key building block in multi-step organic synthesis pathways. It enables the introduction of the 4-(difluoromethoxy)benzenesulfonyl group into complex molecules.
Pharmaceutical Research
A valuable reagent for medicinal chemists exploring new drug candidates. The difluoromethoxy group can modulate pharmacokinetic and pharmacodynamic properties of potential therapeutics.
Agrochemical Development
Employed in the synthesis of new crop protection agents. The fluorinated substituent can enhance the efficacy and metabolic stability of agrochemicals.
Materials Science
Potentially used in the development of specialised polymers or functional materials where its unique electronic or structural properties can be leveraged.
| Molecular weight | 242.63 |
|---|---|
| Linear formula | F2CHOC6H4SO2Cl |
| Assay | 97% |
| Boiling point | 265-266 °C(lit.) |
| Density | 1.523 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5150(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Difluoromethoxy)benzenesulfonyl chloride used for?
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4-(Difluoromethoxy)benzenesulfonyl chloride is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals, owing to its ability to introduce the 4-(difluoromethoxy)benzenesulfonyl moiety.
What is the CAS number and formula for 4-(Difluoromethoxy)benzenesulfonyl chloride?
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The CAS number is 351003-34-4, and its linear formula is F₂CHOC₆H₄SO₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Difluoromethoxy)benzenesulfonyl chloride with an assay of 97%. This product is typically offered for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 4-(Difluoromethoxy)benzenesulfonyl chloride be handled?
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This compound is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Handling requires appropriate personal protective equipment including face shields, gloves, goggles, and suitable respirators. Work should be conducted in a well-ventilated area, and immediate medical attention sought in case of exposure.
Is 4-(Difluoromethoxy)benzenesulfonyl chloride shipped internationally?
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Yes, Tech Serve Solutions specialises in the global supply and export of fine chemicals, including 4-(Difluoromethoxy)benzenesulfonyl chloride, to meet international research and industrial demands.
How can I request a quote or sample?
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To request a quote or a sample of 4-(Difluoromethoxy)benzenesulfonyl chloride, please contact our sales team through the website or direct email, providing your specific requirements.
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