4-(Difluoromethoxy)-3-hydroxybenzaldehyde
4-(Difluoromethoxy)-3-hydroxybenzaldehyde (CAS: 151103-08-1) is an organic compound with the molecular formula C8H6F2O3 and a molecular weight of 188.13 g/mol. This benzaldehyde derivative features both a difluoromethoxy and a hydroxyl group, making it a valuable intermediate in organic synthesis. It serves as a key building block in the development of diverse chemical entities, particularly in the pharmaceutical and agrochemical sectors.
- IUPAC
- 3-Hydroxy-4-difluoromethoxybenzaldehyde
- Synonyms
- 3-Hydroxy-4-difluoromethoxybenzaldehyde

Pharmaceutical Intermediates
Utilised in the synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules. Its unique structural features allow for the introduction of specific functionalities in target compounds.
Agrochemical Development
Serves as a precursor for novel pesticides, herbicides, and fungicides. The incorporation of the difluoromethoxy moiety can influence the biological activity and metabolic stability of agrochemical agents.
Organic Synthesis Building Block
A versatile reagent for constructing more complex organic structures. It participates in various reactions characteristic of aldehydes and phenols, enabling diverse synthetic pathways.
Material Science Research
Investigated for potential applications in the development of advanced materials, leveraging its specific chemical properties.
| Molecular weight | 188.13 |
|---|---|
| Empirical formula | C8H6F2O3 |
| Assay | 95% |
| Melting point | 85-90 °C |


Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38-51 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Difluoromethoxy)-3-hydroxybenzaldehyde used for?
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4-(Difluoromethoxy)-3-hydroxybenzaldehyde is primarily used as a building block in organic synthesis, particularly for creating pharmaceutical intermediates and in agrochemical development.
What are the CAS number and formula for 4-(Difluoromethoxy)-3-hydroxybenzaldehyde?
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The CAS number is 151103-08-1, and the molecular formula is C8H6F2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Difluoromethoxy)-3-hydroxybenzaldehyde with an assay of 95%. This product is not supplied as USP, BP, EP, or any pharmacopoeia grade.
How should 4-(Difluoromethoxy)-3-hydroxybenzaldehyde be handled?
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Handle with care. This compound is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It is also toxic to aquatic life with long-lasting effects (H411). Ensure adequate ventilation and wear appropriate personal protective equipment.
Is 4-(Difluoromethoxy)-3-hydroxybenzaldehyde exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-(Difluoromethoxy)-3-hydroxybenzaldehyde.
How can I request a quote or sample for 4-(Difluoromethoxy)-3-hydroxybenzaldehyde?
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Please contact our sales team via the website or by phone to request a quote or sample.
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