4-Chloro-3-fluorophenylmagnesium bromide solution
4-Chloro-3-fluorophenylmagnesium bromide solution (CAS: 170793-00-7), with the linear formula ClC<sub>6</sub>H<sub>3</sub>(F)MgBr and a molecular weight of 233.75, is a valuable organometallic reagent. Supplied as a 0.5 M solution in THF, it is primarily utilized in organic synthesis as a Grignard reagent for introducing the 4-chloro-3-fluorophenyl moiety into various organic molecules. Its reactivity makes it a key intermediate in the preparation of complex chemical compounds.
Organic Synthesis Intermediate
This Grignard reagent serves as a crucial building block in the synthesis of complex organic molecules. It facilitates the formation of new carbon-carbon bonds by reacting with electrophiles such as aldehydes, ketones, and esters.
Aryl Group Introduction
It is employed to introduce the 4-chloro-3-fluorophenyl group into target molecules. This substitution is often a key step in the development of pharmaceuticals and agrochemicals.
Fine Chemical Manufacturing
The reagent is a versatile tool in the fine chemical industry for creating specialized compounds with specific electronic and steric properties due to the presence of both chlorine and fluorine substituents.
| Molecular weight | 233.75 |
|---|---|
| Linear formula | ClC6H3(F)MgBr |
| Boiling point | 65 °C |
| Density | 0.968 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-3-fluorophenylmagnesium bromide solution used for?
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4-Chloro-3-fluorophenylmagnesium bromide solution is primarily used as a Grignard reagent in organic synthesis to introduce the 4-chloro-3-fluorophenyl group into various organic molecules, serving as an intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals.
What are the CAS number and formula for 4-Chloro-3-fluorophenylmagnesium bromide solution?
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The CAS number is 170793-00-7, and the linear formula is ClC<sub>6</sub>H<sub>3</sub>(F)MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a 0.5 M solution in THF. We do not claim USP, BP, or EP grade unless explicitly stated in the product specifications. For specific purity requirements, please contact our sales team.
How should 4-Chloro-3-fluorophenylmagnesium bromide solution be handled?
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This is a highly flammable liquid and vapour (H225), causes serious eye irritation (H319), may cause respiratory irritation (H335), and is suspected of causing cancer (H351). It may also form explosive peroxides. Handle only in a well-ventilated area, away from heat and ignition sources, wearing appropriate personal protective equipment. Store refrigerated between 2-8°C.
Is this chemical a controlled substance?
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The provided data does not indicate that this compound is a controlled substance.
How is this chemical packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions exports this chemical, adhering to all relevant transportation regulations for hazardous materials, including UN 2924 classification for flammable and corrosive liquids.
How can I request a sample or quote?
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To request a sample or quote for 4-Chloro-3-fluorophenylmagnesium bromide solution, please visit the Tech Serve Solutions website or contact our customer service department.
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