Thioridazine hydrochloride
Thioridazine hydrochloride (CAS: 130-61-0), with the molecular formula C21H26N2S2 · HCl, is a chemical compound supplied by TSS. It is recognised for its applications as an intercalating agent in DNA integrity analysis using square-wave voltammetry and as a positive control for assessing the inhibition of cytochrome P4502D6. This compound is an important reagent in biochemical research and cell biology studies.
- IUPAC
- 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
DNA Integrity Analysis
Thioridazine hydrochloride serves as an intercalating agent for the quantitative assessment of double-stranded DNA (dsDNA) integrity. It is employed in square-wave voltammetry (SWV) techniques for precise electrochemical analysis.
Cytochrome P450 Inhibition Studies
This compound has been utilised as a positive control in studies investigating the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6). Research is conducted using human liver microsomes.
Biochemical Research
As a bioactive small molecule, Thioridazine hydrochloride is applied in various biochemical and cell biology research areas, including cell signalling and neuroscience, contributing to a deeper understanding of biological pathways.
| Molecular weight | 407.04 |
|---|---|
| Empirical formula | C21H26N2S2 · HCl |
| Assay | ≥99% |
| Solubility | H2O: soluble250 mg plus 5 ml of solvent, clear, colorless to faintly yellowchloroform: solublediethyl ether: insolubleethanol: solublemethanol: soluble |
| Application | Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques1. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes2. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
- P501Dispose of contents and container per local regulations
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36/37/38-50/53 |
| Safety statements (S) | 26-36-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DRD2(1813) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Thioridazine hydrochloride used for?
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Thioridazine hydrochloride is used as an intercalating agent for DNA integrity analysis via square-wave voltammetry and as a positive control for inhibiting hepatic enzyme cytochrome P4502D6.
What are the CAS number and formula for Thioridazine hydrochloride?
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The CAS number for Thioridazine hydrochloride is 130-61-0, and its empirical formula is C21H26N2S2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Thioridazine hydrochloride with an assay of ≥99%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling Thioridazine hydrochloride?
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Thioridazine hydrochloride is classified as harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It is also toxic to aquatic life with long-lasting effects (H410). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is Thioridazine hydrochloride packed and shipped?
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Thioridazine hydrochloride is packed and shipped according to relevant regulations for hazardous materials, including UN 3077 classification (Environmentally hazardous substance, solid, n.o.s. (Thioridazine hydrochloride), 9, III). TSS ensures compliance with international shipping standards for chemical exports.
How can I request a sample or quote for Thioridazine hydrochloride?
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To request a sample or a quote for Thioridazine hydrochloride, please contact our sales department through the TSS website or by direct inquiry. Provide your contact details and the quantity required.
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