Thiolutin

CAS 87-11-6C8H8N2O2S2Biochemicals & Reagents

Thiolutin (CAS: 87-11-6), a bioactive small molecule with the empirical formula C8H8N2O2S2, is supplied by Tech Serve Solutions. This compound, derived from Streptomyces luteosporeus, possesses antibacterial and antifungal properties. It is primarily utilised in scientific research for its ability to inhibit transcription in yeasts and disrupt endothelial cell adhesion by interfering with Hsp27 interactions with cytoskeletal components.

IUPAC: Farcinicin,N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl),Propiopyvothine

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Thiolutin (C8H8N2O2S2) — chemical structure, CAS 87-11-6; Life Science, fine chemical supplied by Tech Serve Solutions

AntibacterialAntibioticsAntibiotics A to ZAntibiotics T-ZAntifungalBioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by Enzyme

01 /Applications

Inhibition of Endothelial Cell Adhesion

Thiolutin has been employed in research settings to study the mechanisms of endothelial cell adhesion. It acts by disrupting the interactions of Hsp27 with cytoskeletal components, providing insights into cellular processes and potential therapeutic targets.

Transcription Inhibition in Yeasts

As a research tool, Thiolutin is used to inhibit transcription in yeast models. This application aids in understanding gene expression regulation and cellular responses to transcription inhibitors.

Antibacterial and Antifungal Research

With noted antibacterial and antifungal activity, Thiolutin serves as a subject in studies exploring novel antimicrobial agents and their mechanisms of action against various pathogens.

02 /Properties

Molecular weight	228.29
Empirical formula	C8H8N2O2S2
Assay	≥95% (HPLC)
Solubility	DMSO: soluble0.90 - 1.10 mg/ml, clear, yellow
Storage temperature	−20°C
Application	Studies using thiolutin have reported that it blocks endothelial cell adhesion by disrupting the interactions of Hsp27 with cytoskeletal components2. Thiolutin has also been used as a transcription inhibitor in yeasts3.
Biological source	from Streptomyces luteosporeus

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T+
Risk statements (R)	28
Safety statements (S)	45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

87-11-6

MDL number

MFCD07370147

05 /Additional specifications

Shipped In	wet ice

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Thiolutin used for?

Thiolutin is used in scientific research to inhibit transcription in yeasts and to block endothelial cell adhesion by disrupting Hsp27 interactions with cytoskeletal components. It also exhibits antibacterial and antifungal properties.

What is the CAS number and formula for Thiolutin?

The CAS number for Thiolutin is 87-11-6, and its empirical formula is C8H8N2O2S2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Thiolutin with an assay of ≥95% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.

How should Thiolutin be handled safely?

Thiolutin is classified as Danger (GHS06) and carries the hazard statement H300 (Fatal if swallowed). Strict adherence to safety protocols is essential, including the use of appropriate personal protective equipment such as eyeshields, gloves, and respiratory protection, and handling in a well-ventilated area.