5-Nitro-2-oxindole
5-Nitro-2-oxindole (CAS: 20870-79-5), with the molecular formula C8H6N2O3 and a molecular weight of 178.14, is a chemical intermediate. This compound serves as a key building block in the synthesis of various complex organic molecules. Its applications are primarily within research and development, contributing to the creation of novel compounds for pharmaceutical and chemical research, particularly in the development of kinase inhibitors and other biologically active agents.
- IUPAC
- 5-Nitro-1,3-dihydroindole-2-one,NSC 25199,NSC 99066
Synthesis of COX and LOX Inhibitors
5-Nitro-2-oxindole is utilised as a reactant in the synthesis of indolin-2-one derivatives that act as inhibitors for cyclooxygenase (COX-1/2) and lipoxygenase (5-LOX) enzymes. These compounds are investigated for their anti-inflammatory potential.
Preparation of Aurora Kinase Inhibitors
This compound serves as a precursor for the preparation of Aurora kinase inhibitors. Aurora kinases are crucial in cell cycle regulation, making their inhibitors potential candidates for cancer therapeutics.
Development of RET Inhibitors
It is employed in the synthesis of 3-substituted 2-indolinone derivatives that function as RET inhibitors. These targeted therapies are relevant in oncology, particularly for certain types of cancer.
Analogs of Ellipticine
5-Nitro-2-oxindole is used as a reactant for the synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones, which are analogues of the natural product ellipticine and are explored for their potential anti-cancer properties.
PET Imaging Agents
The compound is a reactant in the preparation of [18F]fluorobenzylidene-indolinone, a molecule designed for positron emission tomography (PET) tumour imaging. It acts as a potential tyrosine kinase inhibitor for diagnostic purposes.
Neuroprotective Agents Research
It is a reactant for preparing 3-substituted indolin-2-ones, which are studied for their neuroprotective and neurotoxic effects. This research contributes to understanding neurological disorders and potential treatments.
| Molecular weight | 178.14 |
|---|---|
| Empirical formula | C8H6N2O3 |
| Assay | 97% |
| Application | • Reactant for synthesis of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors1• Reactant for preparation of Aurora kinase inhibitors2• Reactant for synthesis of 3-substituted 2-indolinone RET inhibitors3• Reactant for synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine4• Reactant for preparation of [18F]fluorobenzylidene-indolinone as possible tyrosine kinase inhibitor for PET tumor imaging5• Reactant for preparation of 3-substituted indolin-2-ones as neuroprotective and toxic agents6 |
| Melting point | 233-236 °C |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitro-2-oxindole primarily used for?
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5-Nitro-2-oxindole is primarily used as a building block and reactant in organic synthesis for the development of various complex molecules, including potential pharmaceuticals like kinase inhibitors and anti-inflammatory agents.
What are the CAS number and formula for 5-Nitro-2-oxindole?
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The CAS number for 5-Nitro-2-oxindole is 20870-79-5, and its empirical formula is C8H6N2O3.
What grade and purity does Tech Serve Solutions supply for 5-Nitro-2-oxindole?
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Tech Serve Solutions supplies 5-Nitro-2-oxindole with a purity of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 5-Nitro-2-oxindole be handled safely?
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Handle 5-Nitro-2-oxindole with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, faceshields, and gloves. Avoid breathing dust. Ensure adequate ventilation. It is classified as a Warning with hazards including skin, eye, and respiratory irritation.
Is 5-Nitro-2-oxindole available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 5-Nitro-2-oxindole, and can facilitate international orders.
How can I request a sample or quote for 5-Nitro-2-oxindole?
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To request a sample or a quote for 5-Nitro-2-oxindole, please contact the Tech Serve Solutions sales team through our website or by phone.
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