5-Nitro-2-furoic acid
5-Nitro-2-furoic acid (CAS 645-12-5), with the molecular formula C5H3NO5 and a molecular weight of 157.08 g/mol, is a heterocyclic organic compound. It serves as a valuable building block in chemical synthesis, particularly in the creation of fused heterocyclic systems. This compound is primarily utilised in research and development settings for the synthesis of novel chemical entities.
- IUPAC
- 5-Nitrofuran-2-carboxylic acid

Synthesis of Triazolothiadiazines
5-Nitro-2-furoic acid has been employed in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. This application highlights its utility in constructing complex heterocyclic frameworks.
Preparation of Triazolothiadiazoles
The compound is a precursor for the synthesis of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. This involves its participation in reactions leading to fused heterocyclic ring systems.
Heterocyclic Building Block
As a furan derivative, 5-Nitro-2-furoic acid functions as a versatile building block in organic synthesis. Its functional groups allow for diverse chemical transformations.
| Molecular weight | 157.08 |
|---|---|
| Empirical formula | C5H3NO5 |
| Assay | 98% |
| Application | 5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles1. |
| Melting point | 185-189 °C(lit.) |

Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitro-2-furoic acid used for?
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5-Nitro-2-furoic acid is primarily used as a building block in chemical synthesis, notably in the preparation of fused heterocyclic compounds such as [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles.
What are the CAS number and molecular formula for 5-Nitro-2-furoic acid?
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The CAS number for 5-Nitro-2-furoic acid is 645-12-5, and its molecular formula is C5H3NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Nitro-2-furoic acid with an assay of 98%. This product is intended for laboratory and research use and is not supplied as USP, BP, or EP grade.
How should 5-Nitro-2-furoic acid be handled safely?
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5-Nitro-2-furoic acid is classified as a warning substance (GHS07) and causes serious eye irritation (H319). Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended.
Is 5-Nitro-2-furoic acid a controlled substance?
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Based on the provided data, there is no indication that 5-Nitro-2-furoic acid is a controlled substance.
How is 5-Nitro-2-furoic acid packed and shipped?
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Tech Serve Solutions packs and ships chemicals professionally to meet international export standards, ensuring safe transit.
How can I request a sample or quote for 5-Nitro-2-furoic acid?
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To request a sample or a quote for 5-Nitro-2-furoic acid, please contact our sales department through the website or by phone.
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