4-Chloro-3-fluoroaniline
4-Chloro-3-fluoroaniline (CAS: 367-22-6), with the molecular formula C6H5ClFN and a molecular weight of 145.56 g/mol, is a fluorinated aromatic amine. This compound serves as a valuable intermediate and building block in organic synthesis. Its unique substitution pattern makes it useful for introducing the 4-chloro-3-fluorophenyl moiety into more complex molecular structures, particularly in the development of pharmaceuticals and agrochemicals.
- IUPAC
- 4-Chloro-3-fluorophenylamine
- Synonyms
- 4-Chloro-3-fluorophenylamine
Pharmaceutical Intermediates
Utilised in the synthesis of active pharmaceutical ingredients (APIs), where the fluorinated aniline structure is incorporated into drug candidates for enhanced metabolic stability or binding affinity.
Agrochemical Synthesis
Serves as a key building block for the development of novel pesticides, herbicides, and fungicides, leveraging the unique properties conferred by the chlorine and fluorine substituents.
Material Science
Employed in the creation of specialized polymers and functional materials where its specific electronic and structural properties can be exploited.
Organic Synthesis Reagent
Acts as a versatile reagent in academic and industrial research for constructing complex organic molecules through various coupling and substitution reactions.
| Molecular weight | 145.56 |
|---|---|
| Empirical formula | C6H5ClFN |
| Assay | ≥97.0% (GC)97.0-103.0% (NT) |
Hazard statements
- H302Harmful if swallowed
- H311Toxic in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H331Toxic if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Flash point | 60 - 62 °C / 140 - 143.6 °F |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 36/37/39-38-45-63 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Chloro-3-fluoroaniline used for?
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4-Chloro-3-fluoroaniline is primarily used as a building block and intermediate in organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and advanced materials.
What is the CAS number and chemical formula for 4-Chloro-3-fluoroaniline?
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The CAS number is 367-22-6 and the chemical formula is C6H5ClFN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Chloro-3-fluoroaniline with an assay of ≥97.0% by GC and 97.0-103.0% by NT. This product is supplied for research and development purposes and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Chloro-3-fluoroaniline be handled safely?
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4-Chloro-3-fluoroaniline is a dangerous substance. It is harmful if swallowed, toxic in contact with skin, and toxic if inhaled. It also causes skin irritation, serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment (gloves, eye protection, respiratory protection) in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for comprehensive safety information.
How is 4-Chloro-3-fluoroaniline packed and shipped?
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This chemical is classified under UN 2811, Hazard Class 6.1 (Toxic substances), Packing Group III, and is shipped according to international regulations for hazardous materials.
How can I request a quote or sample for 4-Chloro-3-fluoroaniline?
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Please contact our sales team via the website or direct email to request a quote or a sample of 4-Chloro-3-fluoroaniline.
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