4-Acetamidophenylboronic acid pinacol ester
4-Acetamidophenylboronic acid pinacol ester (CAS 214360-60-8, C14H20BNO3) is a valuable aryl boronate ester with a molecular weight of 261.12. This compound serves as a key intermediate in organic synthesis, particularly in cross-coupling reactions. Its structure facilitates the introduction of the 4-acetamidophenyl moiety into various molecular architectures, making it important for the development of pharmaceuticals and advanced materials.
- IUPAC
- 4′-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide,4-Acetamidophenylboronic acid, pinacol cyclic ester
- Synonyms
- 4′-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide4-Acetamidophenylboronic acid, pinacol cyclic ester
Suzuki-Miyaura Coupling Reactions
As a boronate ester, this compound is a proficient coupling partner in palladium-catalysed Suzuki-Miyaura reactions. It enables the formation of carbon-carbon bonds, facilitating the synthesis of complex biaryl systems relevant to medicinal chemistry.
Pharmaceutical Intermediate
The 4-acetamidophenyl group is a substructure found in several pharmacologically active compounds. This boronate ester acts as a building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
Materials Science
Its ability to participate in cross-coupling reactions makes it useful for constructing functional organic materials, such as those used in organic electronics or polymer synthesis, where precise molecular architecture is critical.
| Molecular weight | 261.12 |
|---|---|
| Empirical formula | C14H20BNO3 |
| Assay | 97% |
| Melting point | 160-164 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Acetamidophenylboronic acid pinacol ester used for?
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4-Acetamidophenylboronic acid pinacol ester is primarily used as an intermediate in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions for the construction of complex molecules, including pharmaceutical candidates and functional materials.
What are the CAS number and chemical formula?
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The CAS number for 4-Acetamidophenylboronic acid pinacol ester is 214360-60-8, and its empirical formula is C14H20BNO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Acetamidophenylboronic acid pinacol ester with an assay of 97%. This is a technical/research grade, and TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
What are the safety precautions for handling this chemical?
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This compound is classified with GHS07, signal word Warning, and hazard statements H315, H319, H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle with appropriate ventilation.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed according to industry standards to ensure safety and integrity during transit. Tech Serve Solutions has extensive experience in exporting fine chemicals globally, adhering to all relevant shipping regulations.
How can I request a sample or a quote?
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To request a sample or a quote for 4-Acetamidophenylboronic acid pinacol ester, please contact our sales department via the website or by telephone. Our team will respond promptly to your inquiry.
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