4-Acetamidophenylboronic acid
4-Acetamidophenylboronic acid (CAS: 101251-09-6) is an organic compound with the linear formula CH₃CONHC₆H₄B(OH)₂ and a molecular weight of 178.98 g/mol. As a member of the aryl boronic acid class, it serves as a crucial reactant in various synthetic pathways. Its applications span the development of novel therapeutics, including kinase inhibitors and modulators of the survival motor neuron protein, as well as in advanced organic synthesis reactions like cross-coupling and cyanation.
- IUPAC
- 4-Acetamidobenzeneboronic acid
- Synonyms
- 4-Acetamidobenzeneboronic acid
Synthesis of TpI2 Kinase Inhibitors
4-Acetamidophenylboronic acid is utilized as a key building block in the synthesis of TpI2 kinase inhibitors, contributing to the development of potential pharmaceutical agents.
Biological Evaluation of SMN Protein Modulators
This compound plays a role in the biological evaluation of molecules designed to modulate the survival motor neuron (SMN) protein, an area of research for neurological disorders.
Organic Cross-Coupling Reactions
It serves as a reactant in palladium-catalyzed cross-coupling reactions with conjugated dienes, terminal alkenes, and diazoesters, enabling the formation of complex organic structures.
Synthesis of Tetrabutylammonium Trifluoroborates
4-Acetamidophenylboronic acid is employed in the synthesis of tetrabutylammonium trifluoroborates, which are valuable reagents in organic chemistry.
Rhodium-Catalyzed Cyanation
The compound is involved in rhodium-catalyzed cyanation reactions, providing a route to incorporate cyano groups into organic molecules.
| Molecular weight | 178.98 |
|---|---|
| Linear formula | CH3CONHC6H4B(OH)2 |
| Application | Reactant involved in:• Synthesis of TpI2 kinase inhibitors1• Biological evaluation of modulators of survival motor neuron protein2• Cross-coupling with conjugated dienes or terminal alkenes3 or diazoesters4• Synthesis of tetrabutylammonium trifluoroborates5• Rhosium-catalyzed cyanation6 |
| Melting point | 215-220 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of 4-Acetamidophenylboronic acid?
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4-Acetamidophenylboronic acid is primarily used as a reactant in the synthesis of TpI2 kinase inhibitors, for the biological evaluation of modulators of the survival motor neuron protein, in various cross-coupling reactions, the synthesis of tetrabutylammonium trifluoroborates, and rhodium-catalyzed cyanation.
What is the CAS number and molecular formula for 4-Acetamidophenylboronic acid?
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The CAS number is 101251-09-6, and the linear molecular formula is CH₃CONHC₆H₄B(OH)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. Purity information is available on the Certificate of Analysis. We do not represent this product as USP, EP, BP, or pharmacopoeia grade.
How should 4-Acetamidophenylboronic acid be handled safely?
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When handling 4-Acetamidophenylboronic acid, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. Refer to the Safety Data Sheet for comprehensive handling and safety information.
Is 4-Acetamidophenylboronic acid a controlled substance?
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The provided data does not indicate that 4-Acetamidophenylboronic acid is a controlled substance.
How is 4-Acetamidophenylboronic acid packed and shipped?
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Tech Serve Solutions packs and ships chemicals in compliance with all relevant international and national regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a sample or quote for 4-Acetamidophenylboronic acid?
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To request a sample or a quotation for 4-Acetamidophenylboronic acid, please contact our sales department through the website or by phone, specifying your requirements.
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