Methyl coumalate
Methyl coumalate (CAS 6018-41-3; C7H6O4; molar mass 154.12 g/mol), also known as methyl 2-oxo-2H-pyran-5-carboxylate, is a crystalline 2-pyrone building block supplied by Tech Serve Solutions at 98% assay. The electron-poor pyranone ring makes it a versatile diene and reagent in cycloaddition and annulation chemistry, widely used across pharmaceutical-intermediate and fine-chemical synthesis. TSS supplies it as a research/technical-grade reagent for laboratory and process development.
- IUPAC
- Methyl 2-pyrone-5-carboxylate,Methyl 2-oxo-2H-pyran-5-carboxylate
- Synonyms
- Methyl coumalateMethyl 2-pyrone-5-carboxylateMethyl 2-oxo-2H-pyran-5-carboxylateMethyl 2H-pyran-2-one-5-carboxylateCoumalic acid methyl ester
Heterocyclic building block
Serves as a 2-pyrone (pyranone) scaffold for constructing functionalised aromatic and heterocyclic systems. The 5-carbomethoxy group offers a defined handle for further synthetic elaboration.
Diels-Alder and cycloaddition diene
The electron-poor 2-pyrone ring acts as a diene in inverse-electron-demand Diels-Alder reactions, with subsequent loss of carbon dioxide giving access to substituted benzene and arene derivatives.
Annulation reagent
Methyl coumalate has been used as a reagent in phosphine-catalysed [4+3] annulation of modified allylic carbonates, enabling ring-forming routes to more complex frameworks.
Pharmaceutical and fine-chemical intermediate
Used as a versatile intermediate in the synthesis of pharmaceutical candidates, agrochemicals and other fine chemicals where a functionalised pyranone or derived aromatic core is required.
Research and process development
Applied in academic and industrial laboratories for methodology studies and route scouting that exploit the reactivity of the pyranone system.
| Molecular weight | 154.12 |
|---|---|
| Empirical formula | C7H6O4 |
| Assay | 98% |
| Boiling point | 178-180 °C/60 mmHg(lit.) |
| Application | Methyl coumalate has been used as reagent in phosphine-catalyzed [4+3] annulation of modified allylic carbonates1. |
| Melting point | 65-67 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl coumalate used for?
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Methyl coumalate is used mainly as a heterocyclic building block and reagent in organic synthesis. As an electron-poor 2-pyrone it functions as a diene in Diels-Alder and cycloaddition reactions and as a reagent in phosphine-catalysed [4+3] annulations, supporting the preparation of aromatic compounds, pharmaceutical intermediates and fine chemicals.
What is the CAS number and molecular formula of Methyl coumalate?
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The CAS number of Methyl coumalate is 6018-41-3 and its molecular formula is C7H6O4, with a molecular weight of 154.12 g/mol. It is also identified by EC number 227-871-1, MDL number MFCD00010120 and Beilstein registry number 126301.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl coumalate at a typical assay of 98%, as a research/technical-grade reagent suitable for laboratory and process-development use. We do not represent this product as USP, BP or EP pharmacopoeial grade. A current specification or certificate of analysis can be provided on request.
What are the safety and handling precautions for Methyl coumalate?
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Handle Methyl coumalate with standard laboratory precautions, wearing eye protection (eyeshields) and gloves, and using an N95 (US) or P1 (EN143) respirator filter where dust or aerosols may form. It is classified WGK 3 (severely hazardous to water in Germany), so prevent release to drains and the environment. Consult the current Safety Data Sheet before use.
How is Methyl coumalate packed, shipped and exported?
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Methyl coumalate is supplied in securely sealed containers appropriate to the order quantity, with full labelling and documentation. As a global supplier and exporter, Tech Serve Solutions arranges compliant packaging and international shipping with the required transport and customs paperwork; specific pack sizes can be quoted on request.
How do I request a sample or quote for Methyl coumalate?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will respond with availability, lead time and a quotation. Samples and a certificate of analysis can be provided to support evaluation.
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