Methyl indole-3-carboxylate
Methyl indole-3-carboxylate (CAS 942-24-5; C10H9NO2; molar mass 175.18 g/mol) is the methyl ester of indole-3-carboxylic acid, an off-white crystalline indole building block melting at about 149-152 °C. Supplied at 99% assay, it serves as a versatile heterocyclic reactant and intermediate in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions is a specialist supplier, manufacturer and exporter of this research-grade reagent for laboratory and process-development use.
- IUPAC
- 3-Methoxycarbonylindole,3-Carbomethoxyindole,Methyl indolyl-3-carboxylate
- Synonyms
- Methyl indole-3-carboxylate3-Methoxycarbonylindole3-CarbomethoxyindoleMethyl indolyl-3-carboxylateIndole-3-carboxylic acid methyl ester1H-Indole-3-carboxylic acid methyl esterCAS 942-24-5
Heterocyclic building block
Used as a functionalised indole scaffold in chemical synthesis, where the reactive 3-position ester and the indole N-H support further derivatisation. It is a convenient C10 building block for constructing more complex indole-based molecules.
Pharmaceutical intermediate
Serves as a reactant in the preparation of various enzyme and receptor modulators reported in the medicinal-chemistry literature, including nitric oxide synthase (nNOS) inhibitors and protein kinase C alpha (PKCα) inhibitors. Such work is conducted at research and process-development scale.
Kinase and antitumour research
Applied as a starting material for kinase insert domain receptor (KDR) inhibitors and for inhibitors targeting the C-terminal domain of RNA polymerase II investigated as antitumour agents. It supports exploratory drug-discovery programmes.
Receptor antagonist and inhibitor synthesis
Reported as a reactant en route to serotonin 5-HT4 receptor antagonists, very late antigen-4 (VLA-4) antagonists, human 5-lipoxygenase inhibitors and hyaluronidase inhibitors. These uses reflect the indole core's broad relevance in bioactive-molecule design.
Catalysis and methodology studies
Used in the development of organocatalysts for the anti-Mannich reaction and as a substrate in enantioselective Meerwein-Eschenmoser Claisen rearrangement reactions. It is a useful probe for synthetic-methodology research.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 99% |
| Application | Reactant for preparation of:• Nitric oxide synthase (nNOS) inhibitorS1• Protein kinase c alpha (PKCα) inhibitors2• Inhibitors of the C-terminal domain of RNA polymerase II as antitumor agents• Kinase insert domain receptor (KDR) inhibitors3• Organocatalysts for the anti-Mannich reaction4• Very late antigen-4 (VLA-4) antagonists5• Inhibitors of Human 5-Lipoxygenase6• Serotonin 5-HT4 receptor antagonists7• Hyaluronidase inhibitors8Reactant for:• Enantioselective Meerwein-Eschenmoser Claisen rearrangement reactions† |
| Melting point | 149-152 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl indole-3-carboxylate used for?
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Methyl indole-3-carboxylate is used mainly as a heterocyclic building block and pharmaceutical intermediate. It is a reactant in the synthesis of enzyme and receptor modulators reported in the literature, such as nNOS inhibitors, PKCα inhibitors, KDR inhibitors, 5-HT4 receptor antagonists and 5-lipoxygenase inhibitors, and is also applied in synthetic-methodology and catalysis studies.
What is the CAS number and molecular formula of Methyl indole-3-carboxylate?
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The CAS number is 942-24-5 and the molecular formula is C10H9NO2, with a molecular weight of 175.18 g/mol. The MDL number is MFCD00189407 and the PubChem Substance ID is 24864651. It is the methyl ester of indole-3-carboxylic acid.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl indole-3-carboxylate at a typical assay of 99%, as a research/reagent-grade material with a reported melting point of about 149-152 °C. We do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch and detailed specifications are available on request.
What are the safety and handling requirements for Methyl indole-3-carboxylate?
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It is classified under GHS with the signal word Warning (pictogram GHS07) and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow precautionary advice P261 and P305+P351+P338. It is assigned WGK 3 (water-hazard class). Always consult the SDS before use.
How is Methyl indole-3-carboxylate packed, shipped and exported?
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It is supplied in laboratory and bulk pack sizes in tightly closed containers suitable for an irritant solid, with batch labelling and a certificate of analysis. As a specialist exporter, Tech Serve Solutions arranges compliant international documentation and shipping; exact pack sizes and lead times are confirmed at the time of enquiry.
Is Methyl indole-3-carboxylate a controlled or scheduled substance?
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The supplied data does not indicate any drug-control or scheduling status for Methyl indole-3-carboxylate. It is offered as a standard research and fine-chemical building block. Customers remain responsible for confirming the applicable import, handling and end-use requirements in their own jurisdiction.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will provide a quotation, available pack sizes, the certificate of analysis and the safety data sheet. Samples can be arranged for evaluation where appropriate.
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