Methyl indole-5-carboxylate
Methyl indole-5-carboxylate (CAS 1011-65-0) is the methyl ester of indole-5-carboxylic acid, an off-white to pale crystalline solid with the molecular formula C10H9NO2 and a molar mass of 175.18 g/mol (melting point 126-128 degC). It is a versatile heterocyclic building block used in chemical synthesis and medicinal chemistry, notably as a reactant in the preparation of protein kinase inhibitors and indirubin derivatives. Tech Serve Solutions supplies it globally for research and synthesis at 99% assay.
- IUPAC
- Indole-5-carboxylic acid, methyl ester
- Synonyms
- Methyl indole-5-carboxylateIndole-5-carboxylic acid, methyl esterMethyl 1H-indole-5-carboxylate5-(Methoxycarbonyl)indole1H-Indole-5-carboxylic acid methyl ester
Heterocyclic building block
Serves as a functionalised indole scaffold for chemical synthesis and the construction of more complex heterocyclic molecules. The ester group offers a convenient handle for further derivatisation.
Protein kinase inhibitor synthesis
Acts as a reactant in the biosynthesis and preparation of inhibitors of protein kinases, an important class of targets in medicinal chemistry research.
Indirubin derivative preparation
Used as a starting material in the synthesis of indirubin derivatives, bis-indole compounds studied within pharmaceutical and biological research.
Friedel-Crafts and coupling chemistry
Employed as a reactant in metal-free Friedel-Crafts alkylation and in cross dehydrogenative coupling reactions, supporting carbon-carbon bond formation on the indole ring.
Specialised reagent chemistry
Reported as a reactant in the preparation of diphenylsulfonium ylides from Martin's sulfurane and in the synthesis of aminoindolylacetates.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 99% |
| Application | reactant for biosynthesis of inhibitors of protein kinases1reactant in metal-free Friedel-Crafts alkylation2reactant in preparation of diphenylsulfonium ylides from Martin′s sulfurane3reactant in cross dehydrogenative coupling reactions4reactant in synthesis of indirubin derivatives5reactant in preparation of aminoindolylacetates6 |
| Melting point | 126-128 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl indole-5-carboxylate used for?
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Methyl indole-5-carboxylate is used primarily as a heterocyclic building block in chemical synthesis and medicinal chemistry. Documented uses include the preparation of protein kinase inhibitors and indirubin derivatives, metal-free Friedel-Crafts alkylation, cross dehydrogenative coupling reactions, and the synthesis of aminoindolylacetates.
What is the CAS number and molecular formula of Methyl indole-5-carboxylate?
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The CAS number is 1011-65-0 and the molecular formula is C10H9NO2 (Hill notation), giving a molecular weight of 175.18 g/mol. The MDL number is MFCD00153023 and the PubChem Substance ID is 24873426. It is also known as indole-5-carboxylic acid, methyl ester.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl indole-5-carboxylate at a typical assay of 99% as a research and synthesis grade material. We do not represent it as a USP, BP or EP pharmacopoeial grade. A Certificate of Analysis accompanies each batch, and specifications can be confirmed against your requirements on request.
What are the safety and handling requirements for Methyl indole-5-carboxylate?
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It is classified under GHS07 with the signal word Warning. The hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with a dust mask (type N95), eye shields and gloves; avoid dust formation and use adequate ventilation (P261, P305+P351+P338). Consult the Safety Data Sheet before use. WGK (German water hazard class) is 3.
How is Methyl indole-5-carboxylate packed, shipped and exported?
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The product is packed in sealed, appropriately labelled containers sized to the ordered quantity, from research scale to larger commercial volumes. Tech Serve Solutions exports worldwide with full documentation, including a Certificate of Analysis and Safety Data Sheet, and packaging is prepared to meet applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity specification and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for qualification where appropriate.
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