(2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone
(2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone (CAS: 346440-54-8) is a chiral organocatalyst with a molecular weight of 246.35 g/mol. This compound, derived from MacMillan imidazolidinone chemistry, excels in metal-free asymmetric catalysis. It is highly effective in promoting asymmetric indole alkylations, Friedel-Crafts alkylations, and various conjugate addition reactions, achieving high enantiomeric excess in synthetic applications.
- IUPAC
- (2S,5S)-2-tert-Butyl-3-methyl-5-phenylmethyl-4-imidazolidinone,(2S,5S)-5-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone
- Synonyms
- (2S,5S)-5-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone(2S,5S)-2-tert-Butyl-3-methyl-5-phenylmethyl-4-imidazolidinone
Asymmetric Catalysis
Utilised as a Metal-free OrganoCatalyst™ for a variety of asymmetric transformations. It facilitates reactions such as indole alkylations and Friedel-Crafts alkylations with excellent enantioselectivity.
Conjugate Addition Reactions
Effective in catalysing a broad range of conjugate addition reactions. The catalyst enables the formation of chiral products with high enantiomeric excess, crucial for complex molecule synthesis.
Chiral Synthesis
Serves as a key reagent in chiral synthesis, enabling the stereoselective construction of molecules. Its utility is particularly noted in the development of new synthetic methodologies.
| Molecular weight | 246.35 |
|---|---|
| Empirical formula | C15H22N2O |
| Assay | 97% |
| Application | Metal-free OrganoCatalyst™ technology for asymmetric catalysis. Catalyzes asymmetric indole alkylations, Friedel-Crafts alkylations, and a broad range of conjugate addition reactions in high enantiomeric excess.1 |
| Melting point | 93-100 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone used for?
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This compound functions as a metal-free organocatalyst, primarily employed in asymmetric synthesis for reactions like indole alkylations, Friedel-Crafts alkylations, and conjugate additions, achieving high enantiomeric excess.
What is the CAS number and molecular formula for this chemical?
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The CAS number is 346440-54-8, and its empirical formula is C15H22N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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When handling, ensure adequate ventilation and wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK Germany rating of 3, indicating it is hazardous to water.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed according to industry standards to ensure safety during transit. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, facilitating international shipments.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales team through the website or by phone. Provide the product name and CAS number (346440-54-8) for prompt service.
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