2-Amino-4-chloro-5-nitrophenol
2-Amino-4-chloro-5-nitrophenol (CAS: 6358-07-2), with the molecular formula H2NC6H2(Cl)(NO2)OH and a molecular weight of 188.57 g/mol, is a versatile organic building block. This compound serves as a key intermediate in chemical synthesis, particularly in the development of complex molecules and pharmaceutical research. Supplied with an assay of 98%, it is suitable for a range of research and development applications.
Synthesis of Duocarmycin Analogues
2-Amino-4-chloro-5-nitrophenol has been utilised in synthetic pathways for creating achiral analogues of duocarmycin SA (DUMSA). This application highlights its role in the development of potential therapeutic agents.
Organic Synthesis Intermediate
As a functionalised phenol derivative, this compound is valuable in organic synthesis. Its reactive groups allow for further chemical modifications, enabling the construction of more intricate molecular architectures.
Research and Development
The compound's structure makes it a useful reagent in various R&D projects, particularly in medicinal chemistry and the exploration of novel organic compounds.
| Molecular weight | 188.57 |
|---|---|
| Linear formula | H2NC6H2(Cl)(NO2)OH |
| Assay | 98% |
| Application | 2-Amino-4-chloro-5-nitrophenol was used in the synthesis of achiral analogs of duocarmycin SA (DUMSA)1. |
| Melting point | 225 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-4-chloro-5-nitrophenol used for?
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2-Amino-4-chloro-5-nitrophenol is primarily used as a building block in organic synthesis, notably in the preparation of achiral analogues of duocarmycin SA, and for general research and development purposes in chemical and pharmaceutical sectors.
What is the CAS number and molecular formula?
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The CAS number for 2-Amino-4-chloro-5-nitrophenol is 6358-07-2, and its molecular formula is H2NC6H2(Cl)(NO2)OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-4-chloro-5-nitrophenol with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 2-Amino-4-chloro-5-nitrophenol be handled?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask type N95 (US). Avoid breathing dust and ensure adequate ventilation. This compound is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and respiratory irritation.
How is this chemical packed and shipped?
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This chemical is available for purchase and export globally. It is carefully packed to ensure integrity during transit, adhering to international shipping regulations for chemical substances.
How can I request a sample or quote?
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To request a sample or a quote for 2-Amino-4-chloro-5-nitrophenol, please contact our sales team through the website or via email, providing your specific requirements.
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