2-Amino-4-bromophenol
2-Amino-4-bromophenol (CAS 40925-68-6) is a valuable organic building block with the molecular formula C6H6BrNO and a molecular weight of 188.02 g/mol. This compound is primarily utilised as a reactant in various chemical synthesis pathways, including the preparation of complex heterocyclic compounds and biologically active molecules. Its structure lends itself to diverse organic transformations, making it a key intermediate in research and development across multiple scientific disciplines.
- IUPAC
- 4-Bromo-2-aminophenol,NSC 523846
Synthesis of Heterocyclic Compounds
Used as a reactant in the preparation of (aryl)oxadiazolobenzoxazinones via Suzuki-Miyaura coupling reactions. It also serves in the synthesis of benzoxazole benzenesulfonamides which act as allosteric inhibitors.
Medicinal Chemistry Research
A key intermediate in the synthesis of N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives explored as protein tyrosine phosphatase 1B inhibitors. Also employed in developing lipophilic deoxy-xylulose-phosphate reductoisomerase inhibitors.
C-H and C-N Bond Activation
Applicable in copper-catalyzed oxidative amination reactions involving benzoxazoles and related azoles, facilitating C-H and C-N bond activation for novel compound development.
| Molecular weight | 188.02 |
|---|---|
| Empirical formula | C6H6BrNO |
| Assay | ≥98.0% (HPLC) |
| Application | Reactant for:• Preparation of (aryl)oxadiazolobenzoxazinones via Suzuki-Miyaura reaction1• Copper-catalyzed oxidative amination of benzoxazoles and related azoles via C-H and C-N bond activation2• Synthesis of N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as protein tyrosine phophatase 1B inhibitors3• Preparation of lipophilic deoxy-xylulose-phosphate reductoisomerase inhibitors4• Synthesis of benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase5 |
| Melting point | 130-135 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38-42/43 |
| Safety statements (S) | 22-26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-4-bromophenol used for?
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2-Amino-4-bromophenol (CAS 40925-68-6) is used as a reactant in chemical synthesis, including the preparation of heterocyclic compounds like (aryl)oxadiazolobenzoxazinones and benzoxazole benzenesulfonamides, as well as intermediates for potential pharmaceuticals like protein tyrosine phosphatase 1B inhibitors.
What are the CAS number and molecular formula for 2-Amino-4-bromophenol?
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The CAS number for 2-Amino-4-bromophenol is 40925-68-6, and its molecular formula is C6H6BrNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-4-bromophenol with a purity of ≥98.0% (HPLC). This product is intended for research and laboratory use, and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should 2-Amino-4-bromophenol be handled safely?
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2-Amino-4-bromophenol is classified as dangerous. It is harmful if swallowed, causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, faceshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is 2-Amino-4-bromophenol packed, shipped, and exported?
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2-Amino-4-bromophenol is carefully packed in compliance with international shipping regulations to ensure safe transit. Tech Serve Solutions is a global supplier and exporter experienced in handling chemical shipments worldwide.
How can I request a quote or sample for 2-Amino-4-bromophenol?
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To request a quote or a sample of 2-Amino-4-bromophenol, please visit the Tech Serve Solutions website or contact our sales team directly with your requirements.
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