N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone

CAS 65144-34-5C22H35ClN4O7Biochemicals & Reagents

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone (CAS: 65144-34-5), a synthetic peptide derivative with the molecular formula C22H35ClN4O7, serves as a potent inhibitor. It specifically targets serine proteases, notably neutrophil elastase. This compound is a valuable tool in biochemical research for studying enzyme activity and developing protease inhibitors, contributing to the understanding of various biological processes.

IUPAC: N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone

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N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone (C22H35ClN4O7) — chemical structure, CAS 65144-34-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyD to KElastasegranulocyteEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Serine Protease Inhibition

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is utilized as an inhibitor for serine proteases, with a particular emphasis on its activity against neutrophil elastase. This makes it a key reagent for biochemical assays and enzymatic studies.

Biochemical Research Tool

This compound acts as a valuable research tool for investigating protease function and developing novel protease inhibitors. Its specific mechanism of action aids in understanding the role of proteases in cellular pathways and disease.

Cell Biology Studies

Its application extends to cell biology research, where it can be employed to modulate protease activity within cellular systems. This helps researchers elucidate the impact of proteases on cellular functions and signaling.

02 /Properties

Molecular weight	502.99
Empirical formula	C22H35ClN4O7
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

65144-34-5

MDL number

MFCD00077136

PubChem substance

24896552

Beilstein registry

6167019

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone used for?

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone is used as a potent inhibitor for serine proteases, particularly neutrophil elastase, and serves as a valuable tool in biochemical research and cell biology studies.

What are the CAS number and formula for N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone?

The CAS number is 65144-34-5 and the empirical formula is C22H35ClN4O7.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product as a research-grade chemical. We do not represent it as USP, BP, or EP grade.

How should N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone be handled?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The product has a WGK Germany rating of 3, indicating a high hazard to water.