2-Bromo-2′-chloroacetophenone
2-Bromo-2′-chloroacetophenone (CAS: 5000-66-8) is an organic compound with the linear formula ClC₆H₄COCH₂Br and a molecular weight of 233.49 g/mol. This chemical functions as a valuable intermediate and building block in organic synthesis. It is particularly useful in the preparation of various heterocyclic compounds and complex molecules, finding applications in research and development laboratories for novel compound discovery and process optimisation.

Organic Synthesis Intermediate
Serves as a key intermediate in the synthesis of more complex organic molecules, particularly in the pharmaceutical and agrochemical industries. Its reactive bromine and ketone functionalities allow for diverse chemical transformations.
Building Block for Heterocycles
Utilised in the construction of various heterocyclic ring systems, which are common motifs in many biologically active compounds. This makes it a useful reagent for medicinal chemistry research.
Research and Development
Employed in academic and industrial research laboratories for exploring new synthetic pathways and developing novel chemical entities. Its well-defined reactivity supports method development and proof-of-concept studies.
| Molecular weight | 233.49 |
|---|---|
| Linear formula | ClC6H4COCH2Br |
| Assay | 95% |
| Boiling point | 105 °C/1 mmHg(lit.) |
| Density | 1.602 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.590(lit.) |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 2922 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-2′-chloroacetophenone used for?
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2-Bromo-2′-chloroacetophenone is primarily used as a building block and intermediate in organic synthesis, especially for creating heterocyclic compounds and in research and development for novel molecule discovery.
What are the CAS number and formula for 2-Bromo-2′-chloroacetophenone?
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The CAS number is 5000-66-8, and the linear formula is ClC₆H₄COCH₂Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-2′-chloroacetophenone with an assay of 95%. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How should 2-Bromo-2′-chloroacetophenone be handled safely?
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This compound is classified as corrosive and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including gloves, goggles, face shield, and a suitable respirator, must be worn. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
Is 2-Bromo-2′-chloroacetophenone a controlled substance?
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The provided data does not indicate that 2-Bromo-2′-chloroacetophenone is a controlled substance.
How is 2-Bromo-2′-chloroacetophenone packed and shipped?
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2-Bromo-2′-chloroacetophenone is packed according to regulatory requirements for hazardous materials. TSS exports chemicals globally, adhering to international shipping regulations for dangerous goods.
How can I request a sample or quote for 2-Bromo-2′-chloroacetophenone?
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To request a sample or obtain a quotation, please contact our sales team via the website or by phone, providing your specific requirements and shipping details.
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