5-Fluoro-2-oxindole
5-Fluoro-2-oxindole (CAS: 56341-41-4), a fluorinated heterocyclic compound with the molecular formula C8H6FNO and a molecular weight of 151.14 g/mol, serves as a crucial building block in organic synthesis. It is frequently employed as a reactant in the preparation of diverse biologically active molecules, including pharmaceutical intermediates and potential therapeutic agents targeting various disease pathways.
- IUPAC
- 5-Fluoro-1,3-dihydroindol-2-one,5-Fluoro-2,3-dihydro-2-oxoindole
- Synonyms
- 5-Fluoro-1,3-dihydroindol-2-one, 5-Fluoro-2,3-dihydro-2-oxoindole
Synthesis of GSK-3β Inhibitors
5-Fluoro-2-oxindole is utilized as a key intermediate in the synthesis of glycogen synthase kinase 3 beta (GSK-3β) inhibitors, compounds with potential therapeutic applications in neurological disorders and other conditions regulated by GSK-3β activity.
Development of Antitumor Agents
This fluorinated oxindole derivative acts as a precursor for the development of novel antitumor agents. Research indicates its use in creating compounds that target cancer pathways, contributing to the search for new oncological treatments.
Preparation of Kinase Inhibitors
The compound is a valuable reactant for synthesizing various kinase inhibitors, including those targeting Aurora kinases and CDK2/cyclin A. These inhibitors are instrumental in cancer research and the development of targeted therapies.
Synthesis of Receptor Ligands
5-Fluoro-2-oxindole is employed in the synthesis of non-peptide thrombopoietin (TPO) receptor ligands. These compounds are relevant in the research and development of treatments for conditions related to platelet production.
Generation of Enzyme Inhibitors
It functions as a building block for creating inhibitors of enzymes such as cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX), which are important targets in inflammatory disease research.
| Molecular weight | 151.14 |
|---|---|
| Empirical formula | C8H6FNO |
| Assay | 97% |
| Application | Reactant for preparation of:• Glycogen synthase kinase 3 beta (GSK-3β) inhibitors1• Antitumor agents2• Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors3• Multitargeted Receptor Tyrosine Kinase Inhibitors4• Non-peptide thrombopoietin (TPO) receptor ligands5• Aurora kinase inhibitors6• Inhibitors of cyclin-dependent kinase CDK2/cyclin A7• Selective norepinephrine reuptake inhibitors8• B-cell lymphoma-extra large molecule (Bcl-XL) inhibitor Z369• Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1)10 |
| Melting point | 143-147 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-oxindole used for?
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5-Fluoro-2-oxindole is primarily used as a reactant in the synthesis of various biologically active compounds, including inhibitors for enzymes like GSK-3β, Aurora kinases, COX-1/2, and 5-LOX, as well as antitumor agents and TPO receptor ligands.
What is the CAS number and molecular formula for 5-Fluoro-2-oxindole?
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The CAS number for 5-Fluoro-2-oxindole is 56341-41-4, and its molecular formula is C8H6FNO.
What grade and purity does Tech Serve Solutions supply for 5-Fluoro-2-oxindole?
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Tech Serve Solutions supplies 5-Fluoro-2-oxindole with a minimum purity of 97% (assay). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling recommendations for 5-Fluoro-2-oxindole?
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When handling 5-Fluoro-2-oxindole, appropriate personal protective equipment, including eyeshields and gloves, should be worn. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified with WGK Germany 3, indicating a high hazard to water.
How is 5-Fluoro-2-oxindole packed, shipped, and exported?
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5-Fluoro-2-oxindole is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions, adhering to all relevant shipping regulations for chemical substances.
How can I request a quote or sample of 5-Fluoro-2-oxindole?
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To request a quote or a sample of 5-Fluoro-2-oxindole, please contact our sales team through the Tech Serve Solutions website or by phone, providing your specific requirements.
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