1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (CAS 7226-23-5, C6H12N2O) is a versatile polar aprotic solvent with a molecular weight of 128.17 g/mol. Known commonly as DMPU, it serves as a valuable reagent in chemical synthesis, particularly in coupling reactions. Its properties make it an effective alternative to HMPA in various organic transformations requiring a high-boiling, polar solvent.
- IUPAC
- 1,3-Dimethyl-2-oxohexahydropyrimidine,N,N′-Dimethylpropylene urea,DMPU
- Synonyms
- N,N′-Dimethylpropylene urea1,3-Dimethyl-2-oxohexahydropyrimidineDMPU
Solvent in Organic Synthesis
DMPU functions as a polar aprotic solvent, facilitating a range of organic reactions. It is often employed in nucleophilic substitutions and organometallic chemistry where high polarity and solvation power are required.
Coupling Reactions
This compound is particularly noted for its utility in various coupling reactions, including Grignard reactions and transition-metal-catalyzed couplings. Its ability to dissolve diverse reagents contributes to improved reaction yields and selectivity.
Replacement for HMPA
DMPU is frequently used as a safer alternative to hexamethylphosphoramide (HMPA), a known carcinogen. It offers comparable solvating capabilities for many reactions without the severe health risks associated with HMPA.
| Molecular weight | 128.17 |
|---|---|
| Empirical formula | C6H12N2O |
| Assay | ≥99.0% (GC) |
| Grade | absolute |
| Boiling point | 146 °C/44 mmHg(lit.) |
| Density | 1.06 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.488(lit.)n20/D 1.489 |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
- H361F
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 120 °C / 248 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36-43 |
| Safety statements (S) | 23-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality | over molecular sieve (H2O ≤0.03%) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone used for?
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1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) is primarily used as a polar aprotic solvent and reagent in organic synthesis, particularly in coupling reactions and as a safer alternative to HMPA.
What is the CAS number and formula for 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone?
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The CAS number is 7226-23-5 and the empirical formula is C6H12N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone in absolute grade, with an assay of ≥99.0% (GC) and quality over molecular sieve (H2O ≤0.03%). TSS does not represent this product as USP, BP, or EP grade.
How should 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone be handled safely?
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This compound is classified as Danger. It is harmful if swallowed (H302), causes serious eye damage (H318), and may damage fertility (H361f). Appropriate personal protective equipment, including eyeshields, faceshields, and chemical-resistant gloves, is essential. Ensure adequate ventilation and use a suitable respirator. Handle in accordance with safety data sheets.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs and exports chemicals adhering to international shipping regulations. Specific packaging details depend on the quantity and destination, ensuring safe transit.
How can I request a sample or quote?
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To request a sample or a quotation for 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, please contact our sales department through the website or via direct inquiry, providing your contact details and the required quantity.
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