5-Fluoro-2-nitrophenol
5-Fluoro-2-nitrophenol (CAS: 446-36-6), with the molecular formula FC educible H educible<sub>3</sub>(NO educible 2)OH and a molecular weight of 157.10 g/mol, is a valuable organic building block. This fluorinated phenol is characterised by its nitro and hydroxyl functional groups, making it a versatile intermediate in organic synthesis. It is primarily utilised in the development of complex molecules and pharmaceuticals, particularly in areas requiring fluorinated aromatic compounds.
Synthesis of Anticancer Drug Subunits
5-Fluoro-2-nitrophenol has been employed in the total synthesis of the CC-1065 cyclopropyl-indole (CPI) subunit, a crucial component of potent anticancer agents.
Development of Angiogenesis Inhibitors
This compound serves as a key intermediate in the synthesis of 7-substituted 2H-1,4-benzoxazin-3(4H)-ones, which exhibit therapeutic potential as inhibitors of angiogenesis.
Preparation of Heterocyclic Compounds
It is utilised in the synthesis of complex heterocyclic structures, such as 2-(7-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-2H-isoindoline-1,3-diones.
| Molecular weight | 157.10 |
|---|---|
| Linear formula | FC6H3(NO2)OH |
| Assay | 99% |
| Application | 5-Fluoro-2-nitrophenol has been used in:• total synthesis of the (+/−)-CC-1065 CPI subunit1• synthesis of 2-(7-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-2H-isoindoline-1,3-diones2• 7-substituted 2H-1,4-benzoxazin-3-(4H)-ones, possessing therapeutic potential as inhibitors of angiogenesis3 |
| Melting point | 34-37 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 91 °C / 195.8 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-nitrophenol used for?
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5-Fluoro-2-nitrophenol is used as a building block in organic synthesis, particularly in the development of pharmaceuticals, including anticancer agents and angiogenesis inhibitors.
What is the CAS number and molecular formula for 5-Fluoro-2-nitrophenol?
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The CAS number is 446-36-6 and the molecular formula is FC educible H educible<sub>3</sub>(NO educible 2)OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Fluoro-2-nitrophenol with a minimum assay of 99%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or other pharmacopoeial grades.
How should 5-Fluoro-2-nitrophenol be handled?
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5-Fluoro-2-nitrophenol is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation. Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area.
Is 5-Fluoro-2-nitrophenol a controlled substance?
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Based on the provided data, 5-Fluoro-2-nitrophenol is not listed as a controlled substance.
How is 5-Fluoro-2-nitrophenol packaged and exported?
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5-Fluoro-2-nitrophenol is carefully packaged to ensure safe transit and is available for global export. Please contact us for specific packaging and shipping details.
How can I request a sample or quote for 5-Fluoro-2-nitrophenol?
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To request a sample or a detailed quote for 5-Fluoro-2-nitrophenol, please contact our sales department via the website or direct email, providing your specific requirements.
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