(1R,2S)-(−)-trans-2-(1-Methyl-1-phenylethyl)cyclohexanol
(1R,2S)-(−)-trans-2-(1-Methyl-1-phenylethyl)cyclohexanol (CAS 109527-43-7) is a chiral cyclohexyl-based auxiliary agent with a molecular weight of 218.33 g/mol. This compound is primarily utilised in asymmetric synthesis to achieve high levels of stereochemical control in various organic transformations. Its effectiveness makes it a valuable reagent for chemists engaged in complex molecule synthesis and the development of chiral pharmaceuticals.
- Synonyms
- C6H5C(CH3)2C6H10OH
Chiral Auxiliary in Asymmetric Synthesis
This cyclohexanol derivative functions as a chiral auxiliary, facilitating stereoselective reactions. It is known to provide significant asymmetric induction, comparable to or exceeding that of other common chiral auxiliaries like menthol.
Organic Synthesis Building Block
As an organic building block, it can be incorporated into more complex molecular structures. Its defined stereochemistry makes it particularly useful for creating enantiomerically pure target molecules.
Pharmaceutical Intermediate Development
The compound's chiral nature makes it suitable for use in the synthesis pathways of pharmaceutical intermediates where specific enantiomers are required for drug efficacy and safety.
| Molecular weight | 218.33 |
|---|---|
| Linear formula | C6H5C(CH3)2C6H10OH |
| Assay | 97% |
| Boiling point | 300 °C(lit.) |
| Density | 1.026 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.541(lit.) |
| Optical activity | [α]24/D −29°, c = 1.7 in methanol |
| Application | Cyclohexyl-based chiral auxiliary that provides equal or greater levels of asymmetric induction when compared to menthol or 8-phenylmenthol in a variety of reactions.1,2,3,4 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1R,2S)-(−)-trans-2-(1-Methyl-1-phenylethyl)cyclohexanol used for?
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(1R,2S)-(−)-trans-2-(1-Methyl-1-phenylethyl)cyclohexanol is primarily used as a chiral auxiliary in asymmetric synthesis to achieve high levels of stereochemical control in organic reactions. It also serves as an organic building block in complex molecule synthesis.
What are the CAS number and formula for this chemical?
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The CAS number is 109527-43-7, and its linear formula is C6H5C(CH3)2C6H10OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards, as the provided data does not specify such grades.
What are the key safety considerations for handling this compound?
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When handling, it is essential to use personal protective equipment such as eyeshields and gloves. Refer to the Safety Data Sheet (SDS) for comprehensive handling and hazard information. The flash point is greater than 113 °C.
How is this chemical typically packed and shipped?
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This chemical is available for global export and is typically packed in accordance with international shipping regulations to ensure safe transit.
How can I request a sample or a quote for this product?
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To request a sample or a quote, please use the contact form on our website or contact our sales department directly with your inquiry.
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